Protein Alignment CG3216 and gucy2dl

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: XP_017947350.2
• Gene: gucy2dl / 100489435
• XenbaseID: XB-GENE-29079723
• Length: 1106
• Species: Xenopus tropicalis
• Alignment Length: 1150
• Identity: 386/1150 - (33%)
• Similarity: 586/1150 - (50%)
• Gaps: 183/1150 - (15%)

  Fly    79 VGEMGSTMRVYNVGVLMASHLDSPFDLERCGP---------AVDLALDEINKVFLKPHNITL-LK 133
            :..:|...:.:.|||:      .|:   :|.|         |..||:.:||      ::.|| :.
 Frog    46 MNSLGVDCKNFTVGVV------GPW---QCDPLFSKAFPELAARLAVQKIN------NDATLGIG 95

  Fly   134 KKGSY----PSCSGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPP 194
            .|..|    .:|..::|  |.....:.....||:||......:....|...|:|.:.:
 Frog    96 YKFDYRILQENCETSKA--LVDFSSYDKHSSAFVGPMNPGYCDAATLLGKNWDKAVFS------- 151

  Fly   195 SSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALL 259
                              |...|..: .|||.:||..|......:::..|   ::.|.|.||.::
 Frog   152 ------------------WACINHDL-DDKSSFPTFARTMPAPTKVLFHF---MKYFRWAHVGIV 194

  Fly   260 VDRSELFSWT-VGKNLEYGLRQEGL-LSFVKEL-NGNE---------EEVYENYLKDASMYARVV 312
            ....:|  |. .|:.:...||..|| :..|..: ||.|         ||.::         .||:
 Frog   195 SSNDDL--WVDTGRKVASALRNHGLPIGIVTSMGNGEEGLRATLANIEEAHD---------LRVI 248

  Fly   313 ILSVRGVLV-----RKFMLAAHSLGMTNGEWVFL--DVEIFQSEYWGDKGWEMKDEHDAKARKAY 370
            |:.:..||:     ..|:..||.:|:|:|.:||:  |..::...|.......::...:.||  ||
 Frog   249 IMCMHSVLIGGAEQATFLTQAHEMGLTDGRYVFVPYDTLLYSLPYKNSSYQVLEKNPELKA--AY 311

  Fly   371 EALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTE 435
            :|:|.:::.......::.||:......:    .|..|.::|:...|..|:.:|||..|::....:
 Frog   312 DAVLTITMDYENLSFYEVFAEAKERGEI----KTSVEPQQVSPLFGTIYNAMYLLAKAMSSAWKQ 372

  Fly   436 GGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSA 500
            |..: .|.|:.....|..:.|.|..:..|..|:..:::.:||.|   ||.:.:.....|....:.
 Frog   373 GAWV-SGTNLVDYAKNLEYPGFTQTLYTDGKGNDLSNFVVLDTD---GKVNQLFPTYSVEMSSNL 433

  Fly   501 VH--GKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFST-IMYSVFGLLLFLGLVFLVICLLQK- 561
            |.  ||.|.:|||  .|||....|.| ...|.|:|.... |:..:|||:..|.|..:|:..|.:
 Frog   434 VRFLGKTIRFPGG--TPPPSDSSCWF-DPDTLCIGGIEPYIVILIFGLVFALALCGVVVSYLIRH 495

  Fly   562 ---QMKLSKELNNMSWRVRPDDVLIEMGGM--FGSKGGLQRLDVENISLQQFGIHSGRASIASFT 621
               |::|.|         .|:.:|:.:..:  ...|..:::|:::||        |...||:...
 Frog   496 SILQIQLVK---------GPNKILLSLDDLTFINPKLSMKKLNIDNI--------SDTKSISDCK 543

  Fly   622 SL-------------PPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQA--------RDV 665
            ||             .....:::..::|:.|.:||       ..|.:..|::|:        :|:
 Frog   544 SLKSLTRSLSAKSLGASHETSSVAIYEGDWVWLKK-------FEPGVYHELRQSTTSTLRKMKDL 601

  Fly   666 SHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNS 730
            .:||...|:|...|.  ....|:||:||||||:|:|.||.::|||.|:.||:.|::|||.|||:.
 Frog   602 RNENVNPFLGFFSDC--GIFAIVTEHCSRGSLEDLLRNEDVKLDWMFKSSLLLDLIKGMRYLHHR 664

  Fly   731 DVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCP 795
            |. :||:|:|.||::||||||||:|:|...:.......|......:|.|.|||||....:..  .
 Frog   665 DF-SHGRLKSRNCVVDGRFVLKITDYGYNEVVETQKSPRYSMPPEELFWTAPELLRDQALSR--R 726

  Fly   796 ATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ----CNGFRPLIRERECPPDLLE 856
            .|.:|||:||.|||:|:|.||.||  ....:....|:.||::    |   ||.:...:.|.:.::
 Frog   727 GTFKGDVFSFAIILQEVVVRGPPY--CTSGLSAEEIIRKVKKPPPLC---RPAVAPDQAPLECIQ 786

  Fly   857 LMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQ 921
            ||::||::..|.||||..|....:||.||...|::|.:|..:|||::|||.|:.|:|.:|.:|||
 Frog   787 LMKQCWSELAERRPTFDEIFDQFKTINKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQ 851

  Fly   922 RTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTF 986
            :||:||.|:||..||:.|..|..||||.|..||||||||||||.:.|.|.|::||:.|||||:.|
 Frog   852 KTEKLLSQMLPPSVAEALKTGGTVEPEYFDHVTIYFSDIVGFTTISALSEPIEVVDLLNDLYTLF 916

  Fly   987 DRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRI 1051
            |.::..:||||||||||||:|.||||:.||::|..|||.|:||||.:|.||.:||.|:..::|||
 Frog   917 DAVLCNHDVYKVETIGDAYMVASGLPKRNGNRHTAEIANMSLDILSSVGSFQMRHMPDVPVRIRI 981

  Fly  1052 GMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFG-TFQMEQRGD 1115
            |:|||...|||||..||.||||||||||||||||||.|.:|||:.:|.|||.... .:::|.||.
 Frog   982 GLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNQSTAAILRTLNERYKIELRGK 1046

  Fly  1116 VELKGKGTVTTYWLNSTSEGEARP-PTP---------QILTTDEV 1150
            .||||||...|:||.. .||.::| |.|         ..||.:||
 Frog  1047 TELKGKGVEETFWLVG-KEGFSKPLPRPPDIKPGCVAHGLTAEEV 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	97/443 (22%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	102/293 (35%)
		HNOBA	<891..939	CDD:462234	24/47 (51%)
		CYCc	918..1109	CDD:214485	117/191 (61%)
gucy2dl	XP_017947350.2	PBP1_sensory_GC_DEF-like	57..438	CDD:380594	98/447 (22%)
		PK_GC-2D	550..815	CDD:270945	98/281 (35%)
		HNOBA	<824..869	CDD:462234	23/44 (52%)
		CYCc	849..1041	CDD:214485	117/191 (61%)