DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and npr2

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_031750866.1	Gene:	npr2 / 100488543	XenbaseID:	XB-GENE-993191	Length:	1083	Species:	Xenopus tropicalis

Alignment Length:	1182	Identity:	462/1182 - (39%)
Similarity:	643/1182 - (54%)	Gaps:	168/1182 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 YVNCFSAHPNPRRNDITWDDLNKDISLDSTTSLAGLNASDAGLEQRMYERSRESKSTQLSRYTEV 79
            |.:|..:.|:..|....|..|   ::|.:..:...|.     |..|...||.:|.:
Frog     7 YHSCSGSLPSASRMSGYWCPL---LALRAVPAFCFLL-----LFLRCPSRSHQSVT--------- 54

  Fly    80 GEMGSTMRVYNVGVLMASHLDSPFDLERCGPAVDLALD------------EINKVFLKPHNITLL 132
            |....|:.|    ||..|::...:...|..||:.:|:|            ::..|||..
Frog    55 GNQTLTLAV----VLPESNIRYAWSWPRVAPALRMAMDRAQGELQLLPGYQVKWVFLTS------ 109

  Fly   133 KKKGSYPSCSGARAPGLAAD--MYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPS 195
            :..|   :||...||..|.|  :|...||:  .||.|.:....|||.|.:|..|:|
Frog   110 ELNG---ACSEYVAPLNAVDLKLYHNPDVL--FGPGCVYPSASVARFATHWRLPLI--------- 160

  Fly   196 SEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLV 260
                   |:|.|.         .|..:|...|.|..|......:|....:.:...|||:..|.||
Frog   161 -------TAGALA---------FGFKQDDDHYNTTVRTGPTAIKLGEFVSHLHEHFNWSSRAALV 209

  Fly   261 -------DRSELFSWTVGKNLEYGLRQEGL-LSFVKELNGNEEEVYENYLKDASM---------Y 308
                   ||...|.            .||: |:..||.| |....|:.|.:|..:         .
Frog   210 YHDVKMDDRPHYFI------------IEGVFLALNKEFN-NLTVSYQMYPEDEDIGSVIQFIQNS 261

  Fly   309 ARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGD------KGWEMKDEHDAKAR 367
            .||:.:.....::...||.|....:|:|::||..|::|......|      |.|:  ..|..:.:
Frog   262 GRVIYICGPLEMLHLIMLQAQREKLTDGDYVFFYVDVFGESLRADGAREANKPWQ--GNHSQELK 324

  Fly   368 KAYEALLRVSLLQPTSPKFQDFADNV----RENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMA 428
            :|::.:|.:|..||.:.::.:|...:    :|....:.|::.     :||..|.|:|||.|...|
Frog   325 EAFKTVLVISYHQPENAEYFEFQKKLIQKSKEEFGVELNFSL-----MNFIAGCFHDGVLLYAQA 384

  Fly   429 LNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDL-DPINGKFSVVAHYS 492
            |||||.|||..:||::|.:::.:|..|||||.|.:|.|.||:.|:.:..: |...|.|.||.||:
Frog   385 LNETLREGGSQKDGLSIVKKIQDRQMEGITGTVSMDKNNDRNTDFDLWAMTDHNEGSFEVVGHYN 449

  Fly   493 GVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCV-GNFSTIMYSVFG----LLLFLGLV 552
            |::|..:.. ||.|.|..|  .||.|.|||.|..:...|: ...||:.....|    ||:|....
Frog   450 GINKQINWT-GKPILWLKG--SPPSDSPPCVFNADDPSCLKTTVSTLAIVALGAGLTLLIFGMSS 511

  Fly   553 FLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASI 617
            ||::    :::.|.|||.:|.||:|.:::      .||:.....:.....::|...|
Frog   512 FLIL----RKLMLEKELASMLWRIRWEEL------QFGNSERYHKTAGSRLTLSLRG-------- 558

  Fly   618 ASFTSLPP-----QVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGAC 677
            :|:.||..     |::...|.|||..||||.||.|:::||.|:|:|:|..|||...:..||:|||
Frog   559 SSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFLGAC 623

  Fly   678 IDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCN 742
            ||  .|.:.|:||||.||||:|:||||:|.|||.||.|||:||||||.:||.|.:.:||.|:|.|
Frog   624 ID--PPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSN 686

  Fly   743 CLIDGRFVLKISDFGLRTLTTPSDFVRDQNY--YLKLLWIAPELLPLTTIPGCCPATQRGDVYSF 805
            |::|.||||||:|:||.:..:..:  .|..|  |.|.||.|||||.:|..|  .|.||:||||||
Frog   687 CVVDSRFVLKITDYGLASFRSSCE--ADDAYALYAKKLWTAPELLRMTRPP--APGTQKGDVYSF 747

  Fly   806 GIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNGFRPLIR---ERECPPDLLE-LMEKCWADNQ 866
            ||||:||..|.|.:......:....|:.|||  ||.||..|   :..|..:.|. ||::|||:..
Frog   748 GIILQEIALRNGCFYIQGMDLSPKEIVQKVR--NGQRPYFRPTVDISCHSEELGILMDRCWAEEP 810

  Fly   867 EERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQIL 931
            .:||.|:.|::.|....|....:::|:||:||||||||||.||||:|:....||::.|.||||||
Frog   811 LDRPDFNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQIL 875

  Fly   932 PRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVY 996
            |..||:||..|:.|:.|.|.|||||||||||||.:.|.|:||.||..|||||:.||.||..:|||
Frog   876 PHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVY 940

  Fly   997 KVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAG 1061
            |||||||||:||||||..||..|.||||.|:|.:|.||.:|.:||:|..::::|||:|:|.||||
Frog   941 KVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAG 1005

  Fly  1062 VVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTT 1126
            |||.|||.||||||||||||||||.|:..:||:|||||.:||:|..||:|.|||:|:||||.:.|
Frog  1006 VVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKGKGKMRT 1070

  Fly  1127 YWLNSTSEGEAR 1138
            |||:    ||.|
Frog  1071 YWLH----GEHR 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	122/447 (27%)
		ANF_receptor	107..479	CDD:279440	111/413 (27%)
		PKc_like	616..885	CDD:304357	131/279 (47%)
		TyrKc	627..877	CDD:197581	126/255 (49%)
		HNOBA	<882..939	CDD:285003	31/56 (55%)
		CYCc	918..1109	CDD:214485	122/190 (64%)
		Guanylate_cyc	945..1131	CDD:278633	122/185 (66%)
npr2	XP_031750866.1	PBP1_NPR_B	60..458	CDD:380607	125/457 (27%)
		PK_GC-A_B	555..829	CDD:270944	132/289 (46%)
		HNOBA	<835..883	CDD:400168	30/47 (64%)
		CYCc	862..1046	CDD:214485	119/183 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010