DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3216 and gucy1b1

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001238874.1	Gene:	gucy1b1 / 100150304	ZFINID:	ZDB-GENE-090313-160	Length:	608	Species:	Danio rerio

Alignment Length:	628	Identity:	166/628 - (26%)
Similarity:	250/628 - (39%)	Gaps:	175/628 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   597 RLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQ 661
            ::|...| ||.||       ...|.......|.||.:..|..|.                 |..|
Zfish    60 KMDAGGI-LQMFG-------KMFFEFCQESGYDTILRVLGSNVR-----------------EFLQ 99

  Fly   662 ARDVSHEN--TVRFVG------ACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIH 718
            ..|..|::  |: :.|      .|.|..:...|||..|..|..|:|::            :.:|.
Zfish   100 NLDALHDHLGTI-YPGMRAPSFRCTDAEKGNNLILHYYSEREGLQDIV------------IGIIK 151

  Fly   719 DIVKGMNYLHNSDV---AAHGKLRSCNCLIDGRFVLKISDF----------GL------RTLTTP 764
            .:.:   .:|.:::   ....|...|:.:   :|:::..|.          |.      .|..:|
Zfish   152 TVAQ---QIHGTEIEMKVIQPKSEECDHI---KFLIEEKDSEEEAFYEDLDGFEENGTQETRISP 210

  Fly   765 SDFVRDQNYYL-------------KLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRG 816
            ..|.:...::|             .:..:.|:|.     ||.|                   |..
Zfish   211 YTFCKAFPFHLMFDKDLMLTQCGNAIFRVLPQLQ-----PGVC-------------------NLS 251

  Fly   817 GPYQEARQQMD--VHTILHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEE--RPTFSTIRS 877
            ..:...|..:|  .|.||..:....    ::|.:|      .|:....|:|::|  ....|.:|.
Zfish   252 SVFSLVRPHIDFSFHGILSHINTVF----VLRSKE------GLLNVETAENEDELTGTEISCLRL 306

  Fly   878 NIRTIMKGFCENL----------MDDLLNR-----------------------MEQY--ANNLES 907
            ..:.|.....||:          :|||..|                       .|:|  ...||.
Zfish   307 KGQMISLPETENILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEI 371

  Fly   908 L---VEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCAR 969
            |   ::...|.|..||::|:.|||.:||..||.:|.....|..:.:.:|||.||.||||...|::
Zfish   372 LTDRLQHTLRALEDEKKKTDRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSK 436

  Fly   970 SSPMD----VVNFLNDLYSTFDRIIGFYD---VYKVETIGDAYLVVSGLPEPNGDKHAREIALMA 1027
            .:..:    :||.|||:|:.||.:.....   ||||||:||.|:.||||||| ...||:.|..:|
Zfish   437 HASAEGAIKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYMTVSGLPEP-CTHHAKSICHLA 500

  Fly  1028 LDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKI 1092
            ||::.......:...|   :||.||:|:|.|..||:|::||.|||||:|||..||.|:||:.|||
Zfish   501 LDMMEIAGQVKVDEDP---VQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKI 562

  Fly  1093 HVSSATKAILDKFGT----FQMEQRGDVELKGKGTVTTYWLNS 1131
            :||..|...|.....    |.:|.||.|.:|||......|..|
Zfish   563 NVSEYTYRCLQSVENADPQFHLEYRGPVTMKGKKEPMKVWFLS 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	52/312 (17%)
		TyrKc	627..877	CDD:197581	49/293 (17%)
		HNOBA	<882..939	CDD:285003	24/94 (26%)
		CYCc	918..1109	CDD:214485	85/201 (42%)
		Guanylate_cyc	945..1131	CDD:278633	83/196 (42%)
gucy1b1	NP_001238874.1	HNOB	2..166	CDD:285002	29/146 (20%)
		HNOBA	207..406	CDD:285003	46/232 (20%)
		CYCc	385..584	CDD:214485	86/202 (43%)
		Guanylate_cyc	412..605	CDD:278633	83/196 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810