DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3216 and gucy1a2

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001120379.1	Gene:	gucy1a2 / 100145454	XenbaseID:	XB-GENE-1011801	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	197/718 - (27%)
Similarity:	282/718 - (39%)	Gaps:	195/718 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 RTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPP 516
            ||.:....||    .|.|||:.::              |.:.|...|:...||         |..
Frog    89 RTLQCYEHHV----IGCRDAERNL--------------HNASVRCAYAENSGK---------EDA 126

  Fly   517 PDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDV 581
            .|:  .|.|    .|..|...|.:.  .|....|..|..||..:.:.                 |
Frog   127 EDI--SGIL----QCTANMLGIKFE--ELQERFGEEFFSICFEENER-----------------V 166

  Fly   582 LIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNV 646
            |..:||                :|..|        ...|.:|...:.|:||         ::|.:
Frog   167 LRAVGG----------------TLHDF--------FNGFDALLEHIRTSIG---------RQVTL 198

  Fly   647 KKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLI-------LTEYCSRGSLKDV---- 700
            :    :|..|                    |.:|...|:|:       :..:..:|.:|..
Frog   199 E----SPSFL--------------------CKELADGTLLLSCFHLHHIVGFAMKGLIKAAGKKI 239

  Fly   701 --LENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFG------ 757
              |:.|..::: |.......||::..|:               |||   .|.:|..|..
Frog   240 YQLKVEVEQVN-NVNEKPCPDIIRPGNF---------------NCL---TFKIKECDNANLMKAP 285

  Fly   758 -LRTLTTPSD-------FVRDQNYYLKLLWIAPELLPLTTIPGC-----CPATQRGDVY-SFGII 808
             |::...|||       |.|...::   |...|.:|.|....|.     |...:....: ||.|:
Frog   286 LLQSSHIPSDLRISISTFCRAFPFH---LMFDPNMLILQLGEGLRKLIKCEVHKTMQFHDSFEIV 347

  Fly   809 -------LEEIVNRGGPYQEARQQMDVHTILH--KVRQCNGFRPLIREREC--------PPDLLE 856
                   .|:::.|.......|.:.|..|..:  ||.:..|....:.|...        ...|.|
Frog   348 SPKISCTFEQVLLRLSTPFVIRNKPDAPTFENKDKVMEVKGQMIYVPESSSILFLGSPRVDKLDE 412

  Fly   857 LMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQ-LSLEK 920
            ||.:  ..:..:.|.....|.   .|:.|......|.|..||::....|     |||.| |..||
Frog   413 LMGR--GLHLSDIPIHDATRD---VILVGEQAKAQDGLKKRMDKLKATL-----EKTHQALEEEK 467

  Fly   921 QRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYST 985
            ::|.:|||.|.|..|||||..|..|:..:|..||:.||||||||.:||:.:||.|::.||:||:.
Frog   468 KKTVDLLYSIFPGDVAQQLWEGKSVQARKFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTR 532

  Fly   986 FDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIR 1050
            ||...||.|:||||||||||.|.:||.. ..:.||:.||||||.::..  |..:.......|::|
Frog   533 FDYQCGFLDIYKVETIGDAYCVAAGLLR-QSNSHAKPIALMALKMMEL--SEEVLTPDGRPIKMR 594

  Fly  1051 IGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGD 1115
            ||:|||||.|||||.:||.|||||:.|..||:.||...|.:|:||..|..:|.....|....|..
Frog   595 IGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKDEANFHFVPRSR 659

  Fly  1116 VEL 1118
            .||
Frog   660 EEL 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	10/43 (23%)
		ANF_receptor	107..479	CDD:279440	8/26 (31%)
		PKc_like	616..885	CDD:304357	57/318 (18%)
		TyrKc	627..877	CDD:197581	53/299 (18%)
		HNOBA	<882..939	CDD:285003	23/57 (40%)
		CYCc	918..1109	CDD:214485	94/190 (49%)
		Guanylate_cyc	945..1131	CDD:278633	84/174 (48%)
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<132..248	CDD:377902	31/195 (16%)
		HNOBA	296..486	CDD:369471	49/202 (24%)
		Guanylate_cyc	492..679	CDD:306677	84/174 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910