DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15651 and FKRP

DIOPT Version :9

Sequence 1:	NP_611531.2	Gene:	CG15651 / 37375	FlyBaseID:	FBgn0034567	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001034974.1	Gene:	FKRP / 79147	HGNCID:	17997	Length:	495	Species:	Homo sapiens

Alignment Length:	562	Identity:	133/562 - (23%)
Similarity:	224/562 - (39%)	Gaps:	99/562 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RLRLVKLLLLGFLLANLVFLYYTWNTLLWRRISRALSGESQP----AEEPPKAAKLSPKEKLRNA 65
            ||...:..|...:..||:.|:|    :.|.        :.||    |..|.:|:...|:
Human     2 RLTRCQAALAAAITLNLLVLFY----VSWL--------QHQPRNSRARGPRRASAAGPR------ 48

  Fly    66 NKHIRKSITIVFYGHYNFEQDLKASIDSILDVIPNMPILVLQDGGAEYAYPPVNYER--NLTAGE 128
                   :|::......|:..:...:||.|...|..|::|..|   ...|||:...|  |:
Human    49 -------VTVLVREFEAFDNAVPELVDSFLQQDPAQPVVVAAD---TLPYPPLALPRIPNV---- 99

  Fly   129 ERTVLFQSLSFDVRRTRQELNPLASIRTKYALIMPDGVRLNSKNILQKILREINSMGLPGQPKEQ 193
             |..|.|..   :.|......|...:.|::..::|||.|..:..:|::::..:.:..
Human   100 -RLALLQPA---LDRPAAASRPETYVATEFVALVPDGARAEAPGLLERMVEALRAGS-------- 152

  Fly   194 RPPVPPEQLVRRMVLVPFAGNLKSFSSCVKMNLDLPDWTLELVATNDTRRCDLFLQKHAILLDAA 258
                      .|:|..|.|  ..:.:.|:.:|:.|.:||....|.....|||.......:||.|.
Human   153 ----------ARLVAAPVA--TANPARCLALNVSLREWTARYGAAPAAPRCDALDGDAVVLLRAR 205

  Fly   259 ALAAMPEPFSLPFPEMLYMQAKIANLSTTVFPQAFQEGRR-LFASFHTKQRRMDLRRRQFREMYK 322
            .|..:..|.:.|....|::|..:...:..:....|...|: ..|:.|.:.:.....|.:...:.:
Human   206 DLFNLSAPLARPVGTSLFLQTALRGWAVQLLDLTFAAARQPPLATAHARWKAEREGRARRAALLR 270

  Fly   323 KLQIKRIVRRAYRVPGKAQAREVWGQGHGLVLDGQFSSSNTSLPLITDIDLFGCERTTKSCIGSV 387
            .|.|:.:               .|..|.                    ::.|||.:.|..|.|:|
Human   271 ALGIRLV---------------SWEGGR--------------------LEWFGCNKETTRCFGTV 300

  Fly   388 YNERPYYSYLGKHTPPCCLDKLRTTFNHVLEEFENVGIRYWLDNRALQSAIETNHLSPDAYDIDI 452
            ..:.|.|.|..:.||||||..||.|..:|:...|..|:||||:..:|..|.....:.|..||:|:
Human   301 VGDTPAYLYEERWTPPCCLRALRETARYVVGVLEAAGVRYWLEGGSLLGAARHGDIIPWDYDVDL 365

  Fly   453 SFNVQDLERSNAMKKSQSKPYVDNEGFYWIKATDGHHFRVQFSKPNQVGVNLLP-YSISGTEAKA 516
            ...::|:.....::.:::...||..||.|.||.:|..||||:|:.|.:.|:|.| |..:|...|.
Human   366 GIYLEDVGNCEQLRGAEAGSVVDERGFVWEKAVEGDFFRVQYSESNHLHVDLWPFYPRNGVMTKD 430

  Fly   517 SGFFGWKARSFSADYLHPMSTVLFLGKSVMCPNNVLEYLEEK 558
            :.....:...|...:|.|:..:.|.|.....|||...:||.|
Human   431 TWLDHRQDVEFPEHFLQPLVPLPFAGFVAQAPNNYRRFLELK 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15651	NP_611531.2	None
FKRP	NP_001034974.1	MECDP_synthase	67..>161	CDD:324566	26/122 (21%)
FKRP	NP_001034974.1	LicD	334..>371	CDD:321468	12/36 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140715
Domainoid	1	1.000	79	1.000	Domainoid score	I8773
eggNOG	1	0.900	-	-		E1_28NJB
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11513
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4342
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50106
OrthoDB	1	1.010	-	-		D1115738at2759
OrthoFinder	1	1.000	-	-		FOG0008309
OrthoInspector	1	1.000	-	-		oto91405
orthoMCL	1	0.900	-	-		OOG6_108975
Panther	1	1.100	-	-	LDO	PTHR13627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5818
SonicParanoid	1	1.000	-	-		X6292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800