DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15651 and Fkrp

DIOPT Version :9

Sequence 1:	NP_611531.2	Gene:	CG15651 / 37375	FlyBaseID:	FBgn0034567	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001020849.1	Gene:	Fkrp / 308390	RGDID:	1305852	Length:	494	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	130/564 - (23%)
Similarity:	223/564 - (39%)	Gaps:	103/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LRLVK---LLLLGFLLANLVFLYYTWNTLLWRRISRALSGESQPAEE----PPKAAKLSPKEKLR 63
            :||.:   .|....:|..|||.|.:|.             :.||...    |.:.:.:.|:
  Rat     1 MRLTRCWAALAAAIILNLLVFFYVSWL-------------QHQPRNSRTRGPRRTSAIGPR---- 48

  Fly    64 NANKHIRKSITIVFYGHYNFEQDLKASIDSILDVIPNMPILVLQDGGAEYAYPPVNYER--NLTA 126
                     :|::......|:..:...:||.|.:.|..|::|..|   ...|||:...|  |:
  Rat    49 ---------VTVLIREFEAFDNAVPELVDSFLQLDPAQPVVVAAD---TLPYPPLALPRIPNV-- 99

  Fly   127 GEERTVLFQSLSFDVRRTRQELNPLASIRTKYALIMPDGVRLNSKNILQKILREINSMGLPGQPK 191
               |..|.|..   :.|:.....|...:.|::..::|||.|..|...|::::..:....
  Rat   100 ---RLALLQPA---LDRSAAASRPETYVATEFVALVPDGARAESPGHLERMVEALRGSS------ 152

  Fly   192 EQRPPVPPEQLVRRMVLVPFAGNLKSFSSCVKMNLDLPDWTLELVATNDTRRCDLFLQKHAILLD 256
                        .|:|..|.|  ..:.:.|:.:|:.|.:||..........|||.......:|:.
  Rat   153 ------------ARLVAAPVA--TTNPARCLALNVSLREWTARYGPAPSAPRCDALDGDAVLLMR 203

  Fly   257 AAALAAMPEPFSLPFPEMLYMQAKIANLSTTVFPQAFQEGRR-LFASFHTKQRRMDLRRRQFREM 320
            :..|..:..|.:.|....|::|..:...:..:....|...|: ..|:.|.:.:.....|.:...:
  Rat   204 SRDLFNLSVPLARPLATSLFLQTALRGWAVQLLDLTFASARQPPLATAHARWKAEREGRSRRAAL 268

  Fly   321 YKKLQIKRIVRRAYRVPGKAQAREVWGQGHGLVLDGQFSSSNTSLPLITDIDLFGCERTTKSCIG 385
            .:.|.|:.:               .|..|.                    ::.|||.:.:..|.|
  Rat   269 LRSLGIRLV---------------SWEGGR--------------------LEWFGCSKESPRCFG 298

  Fly   386 SVYNERPYYSYLGKHTPPCCLDKLRTTFNHVLEEFENVGIRYWLDNRALQSAIETNHLSPDAYDI 450
            :|..:.|.|.|.|:.||||||..||.|..:|:...|..|:||||:..:|..|.....:.|..||:
  Rat   299 TVVGDTPAYLYEGRWTPPCCLRALRETARYVVGVLEAAGVRYWLEGGSLLGAARHGDIIPWDYDV 363

  Fly   451 DISFNVQDLERSNAMKKSQSKPYVDNEGFYWIKATDGHHFRVQFSKPNQVGVNLLP-YSISGTEA 514
            |:...::|:.....::.:::...||..||.|.||.:|..||||:|:.|.:.|:|.| |..:|...
  Rat   364 DLGIYLEDVGNCEQLRGAEAGSVVDERGFVWEKAVEGDFFRVQYSESNHLHVDLWPFYPRNGVMT 428

  Fly   515 KASGFFGWKARSFSADYLHPMSTVLFLGKSVMCPNNVLEYLEEK 558
            |.:.....:...|...:|.|:..:.|.|.....|||...:||.|
  Rat   429 KDTWLDHRQDVEFPEHFLQPLVPLAFAGFMAQAPNNYRRFLELK 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15651	NP_611531.2	None
Fkrp	NP_001020849.1	ispDF	67..>163	CDD:236492	28/126 (22%)
Fkrp	NP_001020849.1	LicD	334..>371	CDD:412865	12/36 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334400
Domainoid	1	1.000	80	1.000	Domainoid score	I8449
eggNOG	1	0.900	-	-		E1_28NJB
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11513
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4207
OMA	1	1.010	-	-		QHG50106
OrthoDB	1	1.010	-	-		D1115738at2759
OrthoFinder	1	1.000	-	-		FOG0008309
OrthoInspector	1	1.000	-	-		oto98482
orthoMCL	1	0.900	-	-		OOG6_108975
Panther	1	1.100	-	-	LDO	PTHR13627
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6292
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770