DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9313 and DNAI4

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_079039.4	Gene:	DNAI4 / 79819	HGNCID:	26252	Length:	848	Species:	Homo sapiens

Alignment Length:	733	Identity:	191/733 - (26%)
Similarity:	311/733 - (42%)	Gaps:	144/733 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 KPDDQLDLTEAELGEEITKVLTPTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAFAGNSLHVD 112
            ||...|...|..||.|..     ::.::.:|.:..| ..|:|..:.|..:||:
Human   140 KPSKLLTSQEGSLGSEFI-----SSYSLYQNTINPS-TLGQFTRSVLGSSTVS------------ 186

  Fly   113 SDEGRRQIEESDEIGYPLPMPNYTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDVEEEDD 177
                :..:..|:.|...|..|:|.  .:|.|...|.:...        .|.:..|..||:|:..:
Human   187 ----KSSVSASESIAEDLEEPSYK--RERLTSFTDLQVIR--------AAPEKIVTKEDLEKNIE 237

  Fly   178 EEAKGTE------------GDEGEGEGEGEGAAARQEDDEPAHQAAAVSSKKRKLINQFNYCERG 230
            .....||            ..|.|   |.|....|.::.|       |..:.| |.|.. |.||.
Human   238 IILTETETLRFFDLPTVMVSVESE---EAEKVTQRNKNYE-------VLCRNR-LGNDL-YVERM 290

  Fly   231 ALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSY--MENFAESQKDGT------------KKE 281
            ..|:....:|.|.|.........|.....|.:||||  ||..:.|.|...            .::
Human   291 MQTFNGAPKNKDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQD 355

  Fly   282 ERKRGKREKKFRDKSAIAEQLN--------------------KKYLKCWQILERMINQNIYDDIA 326
            :|..|...:|..:.|::.:..|                    .|:.:....:||::.:||:....
Human   356 QRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKL 420

  Fly   327 HDYRYW--------EDPAD------------EFREGE------------GNLLPLWKFQYDKTKK 359
            ..||..        |:|.|            |.::.|            .||..||.|..|.||.
Human   421 AAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANLERLWSFSCDLTKG 485

  Fly   360 MNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYP 424
            :||:.:.:|.:..||.||.:|...| |:...|..|.:::|||.:|:.|.|:..||...|.....|
Human   486 LNVSSLAWNKTNPDLLAVGYGHFGF-KEQKRGLACCWSIKNPMWPERIYQSPYGVTAVDFSIGAP 549

  Fly   425 FLAVIGLYDGNVAVYNLREDCKEPLYVSRGVNCKHGECVWQIKW-----GLDMADGEVNFF-SVS 483
            .|..:|.::|.:|:||:|.:...|:..|.....||...|||::|     | ...||:.... |:|
Human   550 NLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRG-TTGDGKREILVSIS 613

  Fly   484 SDGRVFNWILMQN-------KLWVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNKIFL 541
            :|||:..|::.:.       :|..||..: .::.|..:..|...::.::.|.|..|||.|..|:|
Human   614 ADGRISKWVIRKGLDCYDLMRLKRTTAAS-NKKGGEKEKKDEALISRQAPGMCFAFHPKDTNIYL 677

  Fly   542 VGTECGYIYKCSTAFSSKYLMTYYAHNMSVYRIDFNRFNSNIFVSCGADWMVKVW--EDMRPDPL 604
            .|||.|:|:|||.:::.:||.||..|...||::.:|.|..::|:||.|||.|.:|  |:::|. |
Human   678 AGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPS-L 741

  Fly   605 FIFDLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKRKNKLTRLSFNEK 669
            ..:...:.|.||.|:|.||.:||| ..|.:|.::||:::....:.:....|  ..|.|.:.|.::
Human   742 SFYPATSVVYDVAWSPKSSYIFAA-ANENRVEIWDLHISTLDPLIVNTANP--GIKFTTILFAKQ 803

  Fly   670 LAFIVVGDEKGVTTSLKL 687
            ...::|||..|..:..:|
Human   804 TDCLLVGDSDGQVSVYEL 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	113/350 (32%)
		WD40 repeat	362..412	CDD:293791	17/49 (35%)
		WD40	413..640	CDD:295369	81/241 (34%)
		WD40 repeat	415..454	CDD:293791	11/38 (29%)
		WD40 repeat	463..505	CDD:293791	16/54 (30%)
		WD40 repeat	513..557	CDD:293791	17/43 (40%)
		WD40 repeat	571..608	CDD:293791	15/38 (39%)
		WD40 repeat	613..654	CDD:293791	14/40 (35%)
DNAI4	NP_079039.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..370		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..464		5/32 (16%)
		WD40	<485..845	CDD:225201	110/344 (32%)
		WD40 repeat	489..534	CDD:293791	15/45 (33%)
		WD40	493..775	CDD:295369	97/286 (34%)
		WD 1. /evidence=ECO:0000255	534..574		12/39 (31%)
		WD40 repeat	539..576	CDD:293791	11/36 (31%)
		WD 2. /evidence=ECO:0000255	583..631		15/48 (31%)
		WD40 repeat	589..640	CDD:293791	14/51 (27%)
		WD 3. /evidence=ECO:0000255	658..698		17/39 (44%)
		WD40 repeat	663..698	CDD:293791	17/34 (50%)
		WD 4. /evidence=ECO:0000255	702..742		15/40 (38%)
		WD40 repeat	707..744	CDD:293791	15/37 (41%)
		WD 5. /evidence=ECO:0000255	745..784		14/39 (36%)
		WD40 repeat	751..786	CDD:293791	13/35 (37%)
		WD 6. /evidence=ECO:0000255	790..829		9/34 (26%)
		WD40 repeat	793..830	CDD:293791	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920