DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and Dnai1

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_780347.2	Gene:	Dnai1 / 68922	MGIID:	1916172	Length:	701	Species:	Mus musculus

Alignment Length:	747	Identity:	327/747 - (43%)
Similarity:	446/747 - (59%)	Gaps:	78/747 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PGKGDGKQVKGKLRTSKNKTDGPGGGGGDADDFDAWMKSRQLLKPDDQLDLTEAELGEEITKVLT 69
            |.|...||.....|.::.:.:..|...|:..  |.|.:|:..::|.|||:||:|||.||.|::||
Mouse     2 PSKQIRKQSISVTRGARRRDEDSGTDVGEGT--DEWSQSKATVRPPDQLELTDAELKEEFTRILT 64

  Fly    70 PTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAF----------AGNSLHVDSDEGRRQIEESD 124
            ..|.:..:|:|.||||||          |..||.|          .||.:..|||||||| ...|
Mouse    65 ANNPHAPQNIVRYSFKEG----------TYKLIGFVNQMAVHFSQVGNLIPKDSDEGRRQ-HYRD 118

  Fly   125 EIGYPLPMPNYTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDVEEEDDEEAKGTEGDEGE 189
            |:                   |.|.:         .:.|....|.|::|||  ||.|     |||
Mouse   119 EM-------------------VAGSQ---------ESIKVVTSEAENLEEE--EEPK-----EGE 148

  Fly   190 GEGEGEGAAARQEDDEPAHQA----------AAVSSKKRKLINQFNYCERGALTYTNPKRNVDTQ 244
            ||.|.|..|..|.|...|.:.          |.|..|:|||.||||:.||.:.|:.||.|:.:.|
Mouse   149 GEAEAEAEAGSQTDIPAAAETTEKVIEEELMAPVQPKERKLTNQFNFSERASQTFNNPLRDRECQ 213

  Fly   245 TIPPPRSQFGANVLQWVIYDSYMENFAESQKDGTKKEERKR----GKREKKFRDKSAIAEQLNKK 305
            ..||||:.|.|...||.|||:|::...:.:|  ||::|:.:    .|.||....|....|..:..
Mouse   214 MEPPPRTNFSATANQWEIYDAYVDELEKQEK--TKEKEKAKTPVAKKTEKMAMRKLTSMESQSDD 276

  Fly   306 YLKCWQ---ILERMINQNIYDDIAHDYRYWEDPADEFREGEGNLLPLWKFQYDKTKKMNVTDILF 367
            ..|..|   |:|||:|||.|||:|.|::|:||.|||:|:.||.||||||||.||.|::.||.:.:
Mouse   277 ITKVTQAAKIVERMVNQNTYDDVAQDFKYYEDTADEYRDQEGTLLPLWKFQNDKAKRLAVTALCW 341

  Fly   368 NPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLY 432
            ||.|.|||||..||:||||| :.|.|.|:::||||||:|:..::.|:||.|:|..:|:|.|:|.|
Mouse   342 NPKYKDLFAVGHGSYDFMKQ-SRGMLLLYSMKNPSFPEYMFSSESGIMCLDVHVDHPYLVVVGYY 405

  Fly   433 DGNVAVYNLREDCKEPLYVSRGVNCKHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNK 497
            |||||:|||::...:|.:.|...:.||.:.|||:||..|..|..:||||||||||:.:|.|::::
Mouse   406 DGNVAIYNLKKPHSQPCFRSTSKSGKHTDPVWQVKWQKDDMDHNLNFFSVSSDGRIVSWTLVKSE 470

  Fly   498 LWVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNKIFLVGTECGYIYKCSTAFSSKYLM 562
            |....||.|..|....:.|:|.::.....|:...||...:.:||||||.|.|||||.::||::|.
Mouse   471 LVHIDIIKLKTEGSTTEIPEGLQLHTVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLD 535

  Fly   563 TYYAHNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFIFDLGAAVGDVKWAPYSSTVFA 627
            ||.||||:|..:.:|.:::.:|:||.:||.||:|:.....|:||:||.:|||||.||||||||||
Mouse   536 TYDAHNMAVDAVLWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFA 600

  Fly   628 AVTTEGKVHVFDLNVNKYKAICIQAVVPKRKNKLTRLSFNEKLAFIVVGDEKGVTTSLKLSPNLR 692
            ||||:||.|||||.||||:|||.|.||.|:|||:|.:.||.....|:|||::|....||||||||
Mouse   601 AVTTDGKAHVFDLAVNKYEAICNQPVVAKKKNKITHVQFNPIHPIIIVGDDRGHIICLKLSPNLR 665

  Fly   693 MMVKPPKKQLYLDQNTLQIGKLEKLLSLVREL 724
            .|.|..|.|.......::|.||:|||:||||:
Mouse   666 KMPKEKKGQEVQKGPAVEIAKLDKLLNLVREV 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	178/352 (51%)
		WD40 repeat	362..412	CDD:293791	27/49 (55%)
		WD40	413..640	CDD:295369	111/226 (49%)
		WD40 repeat	415..454	CDD:293791	19/38 (50%)
		WD40 repeat	463..505	CDD:293791	21/41 (51%)
		WD40 repeat	513..557	CDD:293791	17/43 (40%)
		WD40 repeat	571..608	CDD:293791	13/36 (36%)
		WD40 repeat	613..654	CDD:293791	33/40 (83%)
Dnai1	NP_780347.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..165		22/80 (28%)
		WD40	321..679	CDD:225201	184/358 (51%)
		WD40 repeat	336..382	CDD:293791	27/46 (59%)
		WD40	<354..612	CDD:295369	127/258 (49%)
		WD 1	382..422		18/39 (46%)
		WD40 repeat	388..429	CDD:293791	19/40 (48%)
		WD 2	431..474		22/42 (52%)
		WD40 repeat	436..493	CDD:293791	26/56 (46%)
		WD40 repeat	501..538	CDD:293791	18/36 (50%)
		WD 3	539..579		15/39 (38%)
		WD40 repeat	544..581	CDD:293791	13/36 (36%)
		WD 4	581..621		32/39 (82%)
		WD40 repeat	586..627	CDD:293791	33/40 (83%)
		WD 5	629..668		20/38 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846000
Domainoid	1	1.000	394	1.000	Domainoid score	I770
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8122
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1038
Isobase	1	0.950	-	0	Normalized mean entropy	S5611
OMA	1	1.010	-	-		QHG56518
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007081
OrthoInspector	1	1.000	-	-		otm42488
orthoMCL	1	0.900	-	-		OOG6_104441
Panther	1	1.100	-	-	LDO	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4417
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.750