DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9313 and dic1

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001342791.1	Gene:	dic1 / 5802757	PomBaseID:	SPBC646.17c	Length:	544	Species:	Schizosaccharomyces pombe

Alignment Length:	490	Identity:	112/490 - (22%)
Similarity:	191/490 - (38%)	Gaps:	90/490 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 IYDSYMENFAESQK----------DGTKKEERKRGKREKKFRDKSAI-AEQLNKKYLKCWQILER 315
            :|.||...|..|..          ..|.|..:...|..|.....||: .:.||.......:||:|
pombe    83 VYQSYSSTFNVSNHVPSISKTVNIRETSKHLKHSTKAPKCSLPTSALEIDHLNNFLHSSAKILDR 147

  Fly   316 -MINQNIYDDIAHDYRY-WEDPADEFREGEGNLLPLWKFQYDK-TKKMNVTDILFNPSYYDLFAV 377
             :.:|:  :.:..||.. .:...::.:..|..|..|:.||.:| |....|..|.::..:.:|...
pombe   148 ALCDQS--NQLFTDYTVKKKSKKNKSQLEENGLNHLFTFQDEKITLNSVVNSISYSSFFEELLIT 210

  Fly   378 CFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLR 442
            .:.......:| .|...::..:..:.|:.:::....:..|...|.:|.|...|.|:|.|.:::||
pombe   211 SYAKPKEALRT-RGLAIVWNQRWKNSPESVLKARSEITVCKPSPFHPQLIAGGAYNGQVFLWDLR 274

  Fly   443 EDCKEPLYVSRGVNCKHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLY 507
            :. :.|:..:..::..|.|.|..|.:..:....  |..:.|:||.|..|
pombe   275 QG-QYPVSFTTIISGGHLEPVTDITYINNPPSN--NIVTCSTDGLVHIW---------------- 320

  Fly   508 RENGLVDGPDGTKVTLKS---------GGSCMVFHPVDNKIFLVGTECGYIYKCSTAFSSKYLMT 563
             |..:...|..| :.|.|         ..:|:.|.|.:|..||||.|.|   |....:.|.|..|
pombe   321 -EPDMFSRPSET-ICLSSQVDSSSQCIPATCLSFIPENNMEFLVGAEDG---KLQRGYRSDYSET 380

  Fly   564 ---------YYAHNMSVYRIDFNRFNS-NIF--------VSCGADWMVKVWE--------DMRP- 601
                     |..||:.:..||....|| |:|        ::...||.|::|:        ::.|
pombe   381 KAVQPSNVSYEGHNVFISGIDVMTSNSQNVFLEKNKDFALTSSFDWTVRLWQCSPSRNQHELVPS 445

  Fly   602 ----DPLFI-----FDLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKR 657
                :.:.|     |...|.|.||||.......||:|...|.::::||  .|.....:.:.:|..
pombe   446 NDLDEQVIINSCKTFTHKAMVFDVKWCVSEPCCFASVDALGNLNLWDL--QKDVEAPVTSDIPDG 508

  Fly   658 KNKLTRLSFNEKLAFIVVGDEKGVTTSLK-LSPNL 691
            | .|.::::..:...:..|...|.....| |||||
pombe   509 K-PLNKIAWQPEKRNLACGGLNGNVHIYKHLSPNL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	89/386 (23%)
		WD40 repeat	362..412	CDD:293791	6/49 (12%)
		WD40	413..640	CDD:295369	66/271 (24%)
		WD40 repeat	415..454	CDD:293791	11/38 (29%)
		WD40 repeat	463..505	CDD:293791	8/41 (20%)
		WD40 repeat	513..557	CDD:293791	15/52 (29%)
		WD40 repeat	571..608	CDD:293791	12/63 (19%)
		WD40 repeat	613..654	CDD:293791	12/40 (30%)
dic1	NP_001342791.1	WD40	223..536	CDD:330360	76/339 (22%)
		WD40 repeat	247..289	CDD:293791	11/42 (26%)
		WD40 repeat	294..339	CDD:293791	13/64 (20%)
		WD40 repeat	348..390	CDD:293791	14/44 (32%)
		WD40 repeat	397..453	CDD:293791	11/55 (20%)
		WD40 repeat	466..504	CDD:293791	12/39 (31%)
		WD40 repeat	511..535	CDD:293791	3/23 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810