DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and dync1i2b

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_009300385.1	Gene:	dync1i2b / 561612	ZFINID:	ZDB-GENE-090121-1	Length:	645	Species:	Danio rerio

Alignment Length:	619	Identity:	144/619 - (23%)
Similarity:	252/619 - (40%)	Gaps:	126/619 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 EQRETDNVDG-EEGEG--EEDDD---------------GATAKDAA-VEDEDVEEED-------- 176
            |:|:...:|| :||..  :||.|               |.|  ||: |:...|..||
Zfish    30 EERKKKELDGRKEGASPPQEDSDLERKRREAEALLQSMGIT--DASMVQPLRVVTEDTCLFHYLV 92

  Fly   177 ------DEEAKGT---EGDEGEGEGEGEGAAARQEDDEPA----HQAAAVSSKKRKL----INQF 224
                  ..::.||   .|.:..|:| |.|......|.:|:    |..:.:.....||    :.|.
Zfish    93 PPPMSPSAKSVGTPSETGSQDSGDG-GTGPRTLHWDSDPSTLLLHSDSQLGRGPLKLGMSKVTQV 156

  Fly   225 NYCERGALTYTNPKRNVDTQTIPPPRSQFGAN--------VLQWVIYDSYMENFAESQKDGTKKE 281
            ::..:..::|:.     :|||  |.::....:        |:|.|     ||  .:.:|| ::||
Zfish   157 DFPPKEMVSYSK-----ETQT--PTQTHHKEDEEEEEDLAVMQPV-----ME--PQEEKD-SQKE 206

  Fly   282 ERKRGKREKKFRDKSAI--AEQLNKKYLKCWQILERMINQNIYDDIAHDY--RYWEDPADEFREG 342
            |.:....|....:|..|  :|:....:....:|:||.:::.:  |:..||  |..:|     :||
Zfish   207 EDEASPHELTEEEKQQILHSEEFVTFFDHSSRIMERALSEQV--DVFFDYSGRDLQD-----KEG 264

  Fly   343 E---GNLLPLWKFQYDK--TKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVK-NP 401
            |   |..|.|.:...|:  :|...||.:.::|.|.:|....:.|::......:|...::.:| ..
Zfish   265 ESQAGAKLSLNRQFADERWSKHRVVTCLDWSPQYPELLVASYCSNEEAPHEPDGVALVWNMKYKK 329

  Fly   402 SFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLY---VSRGVNCKHGECV 463
            :.|:|:......||.......:|.|.|.|.|.|.:.:::.|.:.:.|:.   :|...:.....||
Zfish   330 TTPEYVFHCQSAVMSAAFAQFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSASAHTHPVYCV 394

  Fly   464 WQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLYRENGLVDGP-DGTKVTLKSGG 527
            ..:  |...|.   |..|:|:||::.:|.|                 .::..| |..::..|...
Zfish   395 NVV--GTQNAH---NLISISTDGKMCSWSL-----------------DMLSTPQDSLELVFKQSK 437

  Fly   528 S----CMVFHPVDNKIFLVGTECGYIY-KCSTAFSSKYLMTYYAHNMSVYRIDFNRFN-----SN 582
            |    .|.|...|...|:||:|.|.:| .|.....:.....:..|:..:..:|.:...     |:
Zfish   438 SVAVTSMSFPLGDVNNFVVGSEDGSVYTACRHGSKAGISEMFEGHHGPITGLDCHTAAGPVDFSH 502

  Fly   583 IFVSCGADWMVKVWEDMRPDPLFIF-DLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYK 646
            :||:...||.||:|......||:.| |....|.||.|:|....:||.|  :|..|:...|:|...
Zfish   503 LFVTSSFDWTVKLWSTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACV--DGVGHLDLWNLNNET 565

  Fly   647 AICIQAVVPKRKNKLTRLSFNEKLAFIVVGDEKG 680
            .:...:|..:....|.|:.:......:.|||.:|
Zfish   566 EVPTASVTVEGNPALNRVRWAHSGREVAVGDSEG 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	81/346 (23%)
		WD40 repeat	362..412	CDD:293791	10/50 (20%)
		WD40	413..640	CDD:295369	60/241 (25%)
		WD40 repeat	415..454	CDD:293791	10/41 (24%)
		WD40 repeat	463..505	CDD:293791	10/41 (24%)
		WD40 repeat	513..557	CDD:293791	14/49 (29%)
		WD40 repeat	571..608	CDD:293791	12/42 (29%)
		WD40 repeat	613..654	CDD:293791	12/40 (30%)
dync1i2b	XP_009300385.1	Dynein_IC2	145..173	CDD:288403	7/34 (21%)
		Spore_coat_CotO	153..>256	CDD:290858	26/119 (22%)
		WD40	283..605	CDD:295369	80/341 (23%)
		WD40 repeat	289..338	CDD:293791	10/48 (21%)
		WD40 repeat	343..382	CDD:293791	9/38 (24%)
		WD40	362..>606	CDD:225201	62/262 (24%)
		WD40 repeat	391..434	CDD:293791	13/64 (20%)
		WD40 repeat	442..490	CDD:293791	11/47 (23%)
		WD40 repeat	497..528	CDD:293791	10/30 (33%)
		WD40 repeat	534..575	CDD:293791	13/42 (31%)
		WD40 repeat	580..606	CDD:293791	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910