DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and dync1i1

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_009290517.1	Gene:	dync1i1 / 561525	ZFINID:	ZDB-GENE-061215-62	Length:	647	Species:	Danio rerio

Alignment Length:	697	Identity:	142/697 - (20%)
Similarity:	251/697 - (36%)	Gaps:	189/697 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KSRQLLKP-----DDQLDLTEAELGEEITKVLTPTNTNIVRNLVVYSFKEGEF---VPAPL---- 94
            :|..|.:|     |..||....|....:..:.......:|:.|.:.::....|   ||.|:
Zfish    36 ESEMLQRPENVTEDSDLDRKRRETEALLQSIGISPEPPLVQPLQLLTWDTCYFHYLVPTPMSPSS 100

  Fly    95 -----PGNTVTLIAFAG------NSLHVDSDEGRRQIEESDEIGYPLP------------MPNYT 136
                 |..|.:..:..|      .:|..|:|....|:......|..:.            ||...
Zfish   101 QSVSPPSETGSQESIDGGTVERYRTLQWDTDPSALQLLADSVHGCRMQRLGASKIVQIDFMPKEL 165

  Fly   137 VVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDVEEEDDEEAKGTEGDEGEGEGEGEGAAARQ 201
            |...:||                    ...|.....|||||||....:.:....:.|.|    :.
Zfish   166 VTYSKET--------------------QTPVASNQPEEEDDEELSVPKSEPASQQLEEE----KT 206

  Fly   202 EDDEPAHQAAAVSSKKRKLINQFNYCERGALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSY 266
            ::.|..|.....:.:|.:::                                            :
Zfish   207 QEVEEVHPRELTNEEKEQIV--------------------------------------------H 227

  Fly   267 MENFAESQKDGTKKEERKRGKREKKFRDKSAIAEQLNKKYLKCWQILERMINQNIYDDIAHDY-- 329
            .|:|.                   .|.|:|.             :::||::.::  .||..||
Zfish   228 SEDFL-------------------FFFDRSI-------------RVVERVLAED--KDIFFDYSG 258

  Fly   330 RYWEDPADEFREGE---GNLLPLWKFQYDK--TKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTN 389
            |..||     :||:   |:.|...:..||:  :|...||.:.::|.|.:|....:.:::......
Zfish   259 RDMED-----KEGDLQAGSNLSFNRHFYDEHWSKHRVVTSLDWSPQYPELLVASYNTNEDAPHEP 318

  Fly   390 EGYLCLFTVK-NPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLY--- 450
            :|.:.::.:| ..:.|:||......||.......:|.|.:.|.|.|.:|:::.|...:.|:.
Zfish   319 DGVVLVWNMKFKKATPEYIFHCQSSVMSVGFAQFHPNLVIGGTYSGQIAMWDNRSHRRTPVQRTP 383

  Fly   451 VSRGVNCKHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLYRENGLVDG 515
            :|...:.....||..:  |...|:   |..:||:||::.:|.|........::..:|.::..|
Zfish   384 LSATAHTHPVYCVNVV--GTQNAN---NLITVSTDGKMCSWSLDMLSQPQESMELIYNKSKPV-- 441

  Fly   516 PDGTKVTLKSGGSCMVFHPVDNKIFLVGTECGYIYKCSTAFSSKYLMTYY-----------AHNM 569
                .||      ||.|...|...::||:|.|.:|..|...|...:...:           .||
Zfish   442 ----AVT------CMAFPASDVNNYVVGSEEGTVYTASRHGSKAGIGEIFDGHQGPVTGISCHN- 495

  Fly   570 SVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFIFDLGA-AVGDVKWAPYSSTVFAAVTTEG 633
            :|..:||    |::|.:...||.||:|......||:.|:..| .|.||.|:|....:||.|...|
Zfish   496 AVGPVDF----SHLFTTSSFDWTVKLWSTKHNKPLYSFEDNADYVYDVMWSPVHPALFATVDGNG 556

  Fly   634 KVHVFDLNVNKYKAICIQAVVPKRKNKLTRLSFNEKLAFIVVGDEKG 680
            ::.::  |:|.|..:...:|..:....|.|:.:......:.|||.:|
Zfish   557 RLDLW--NLNNYTEVPSASVSVEGGCALNRVRWASGGREVAVGDSEG 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	85/346 (25%)
		WD40 repeat	362..412	CDD:293791	10/50 (20%)
		WD40	413..640	CDD:295369	62/241 (26%)
		WD40 repeat	415..454	CDD:293791	10/41 (24%)
		WD40 repeat	463..505	CDD:293791	10/41 (24%)
		WD40 repeat	513..557	CDD:293791	13/43 (30%)
		WD40 repeat	571..608	CDD:293791	12/36 (33%)
		WD40 repeat	613..654	CDD:293791	12/40 (30%)
dync1i1	XP_009290517.1	Dynein_IC2	147..175	CDD:288403	5/47 (11%)
		WD40	215..608	CDD:225201	104/494 (21%)
		WD40	284..607	CDD:295369	83/342 (24%)
		WD40 repeat	292..337	CDD:293791	7/44 (16%)
		WD40 repeat	347..388	CDD:293791	9/40 (23%)
		WD40 repeat	394..437	CDD:293791	12/47 (26%)
		WD40 repeat	443..490	CDD:293791	13/52 (25%)
		WD40 repeat	498..530	CDD:293791	11/35 (31%)
		WD40 repeat	536..574	CDD:293791	12/39 (31%)
		WD40 repeat	582..608	CDD:293791	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810