DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9313 and dnai4

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001018595.1	Gene:	dnai4 / 553797	ZFINID:	ZDB-GENE-050522-322	Length:	778	Species:	Danio rerio

Alignment Length:	602	Identity:	161/602 - (26%)
Similarity:	256/602 - (42%)	Gaps:	131/602 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 AKDAAVEDEDVEEEDDEEAKGTEGDEGEGEGEGEGAAARQEDDEPAHQAAAVSSKKRKLINQFNY 226
            |...::|.||.|...:.....||..:.           ||.:|:                    |
Zfish   206 AVSVSLESEDAEAVKERNNAYTELCKN-----------RQGNDK--------------------Y 239

  Fly   227 CERGALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSYMENFAESQKDGTKKEER-------- 283
            .||...|:::..:..:.|...............|.:|||: .|.::...:.....||
Zfish   240 VERSMQTFSDAPKTKEVQCDSITMVDKAVMCTVWDMYDSF-NNISDVSANTVVSSERHEATIPES 303

  Fly   284 ---------KRGKR-------------EKKFRDKSAIAEQLNK-----------KYLKCWQILER 315
                     ||..:             .....:|.|....|::           |..:...::||
Zfish   304 SPEGHLVHPKRSNQSLSVVSTVSTVSGSSTHIEKMACVLPLDEEPDLQLILQSDKLKQDLALMER 368

  Fly   316 MINQNIYDDIAHDYRYW---EDP--------ADEFREGEGN-----LLPLWKFQYDKTKKMNVTD 364
            ::..|::......||..   |||        .:.:.|...|     |..||.|..:.|...|||.
Zfish   369 VVLANVFQPKLAAYRQLPIIEDPDCVQMVMEEESWTEQSKNSHCPFLERLWDFSCELTMGRNVTC 433

  Fly   365 ILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYPFLAVI 429
            :::|....||.||.:|..:| |..|.|.:|.:::|||::||.:...:.||...|...:......:
Zfish   434 MVWNKKNPDLLAVGYGQVEF-KNPNSGLVCCWSLKNPTWPDRVFYCESGVTALDFSASNANQLAV 497

  Fly   430 GLYDGNVAVYNLREDCKEPLYVSRGVNCKHGECVWQIKW-----GLDMADGEVNFFSVSSDGRVF 489
            |:|||.:|:||::...:.|:..|......|...|||:.|     ||....||: ..|||||||:.
Zfish   498 GMYDGTIAIYNVQTSEQTPITDSSDCANLHTSPVWQLTWIDHEDGLAADKGEI-LVSVSSDGRIS 561

  Fly   490 NWI---------LMQNKL----WVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNKIFL 541
            .||         ||:.|:    |...|.:|                  :.|.|..|||.|:||:|
Zfish   562 KWIHYKSMECVDLMKLKIHDLQWKQHISSL------------------TPGMCFDFHPNDSKIYL 608

  Fly   542 VGTECGYIYKCSTAFSSKYLMTYYAHNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFI 606
            ||||.|:|:|||::::.:||.:|.||...||::.::.|.|::|:||.:||.:::|......|:..
Zfish   609 VGTEEGHIHKCSSSYNEQYLDSYKAHKRPVYKVTWSPFCSDVFLSCSSDWTIQLWRQDLQIPVMG 673

  Fly   607 FDLG-AAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKRKNKLTRLSFNEKL 670
            |..| ..|.|:.|:|:.:|||.|| :||||.::||.|:......:....|....  |.|.|:.:.
Zfish   674 FTSGQRVVFDIMWSPHCATVFGAV-SEGKVEIWDLRVSSLDPTLVNWTSPGVNP--TALLFSPET 735

  Fly   671 AFIVVGDEKGVTTSLKL 687
            ..::|||.:|..|..||
Zfish   736 DCVLVGDSEGQVTVYKL 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	119/354 (34%)
		WD40 repeat	362..412	CDD:293791	18/49 (37%)
		WD40	413..640	CDD:295369	85/245 (35%)
		WD40 repeat	415..454	CDD:293791	10/38 (26%)
		WD40 repeat	463..505	CDD:293791	22/59 (37%)
		WD40 repeat	513..557	CDD:293791	18/43 (42%)
		WD40 repeat	571..608	CDD:293791	11/36 (31%)
		WD40 repeat	613..654	CDD:293791	16/40 (40%)
dnai4	NP_001018595.1	WD40 repeat	431..473	CDD:293791	16/42 (38%)
		WD40	<459..754	CDD:225201	106/316 (34%)
		WD 1. /evidence=ECO:0000255	477..517		10/39 (26%)
		WD40	479..751	CDD:295369	97/293 (33%)
		WD40 repeat	483..526	CDD:293791	10/42 (24%)
		WD 2. /evidence=ECO:0000255	526..573		18/47 (38%)
		WD40 repeat	531..576	CDD:293791	18/45 (40%)
		WD 3. /evidence=ECO:0000255	586..629		21/60 (35%)
		WD40 repeat	589..624	CDD:293791	19/52 (37%)
		WD 4. /evidence=ECO:0000255	633..673		13/39 (33%)
		WD40 repeat	638..675	CDD:293791	11/36 (31%)
		WD 5. /evidence=ECO:0000255	676..715		17/39 (44%)
		WD40 repeat	681..707	CDD:293791	13/26 (50%)
		WD 6. /evidence=ECO:0000255	721..760		11/34 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820