DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9313 and DYNC2I1

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_006716104.1	Gene:	DYNC2I1 / 55112	HGNCID:	21862	Length:	1069	Species:	Homo sapiens

Alignment Length:	793	Identity:	158/793 - (19%)
Similarity:	275/793 - (34%)	Gaps:	228/793 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 DSDEGRRQ-IEESDEIGYPL---PMPNYTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDV 172
            |.|..|:. .||...:.:.|   |....||| :||.     |:.|.:.::..|.|..|:.||:..
Human   324 DKDSRRKHGHEEGSSVWWKLDQRPGGEETVV-RREI-----EKEETDLENARADAYTASCEDDFE 382

  Fly   173 EEEDDEEAKGTEGDEGEGEGEGEGAAARQEDDE-PAHQAAAVSSKKRKLINQFN----------Y 226
            :.|||.|.  .:||:.|...|.|   :|::.:| |..|...:...:| .||..|          :
Human   383 DYEDDFEV--CDGDDDESSNEPE---SREKLEELPLAQKKEIQEIQR-AINAENERIGELSLKLF 441

  Fly   227 CERGALTYTNPKRNVDTQTIPPPRSQFG-------------------------ANVLQWV----- 261
            .:||...:....| .||.:.|...|..|                         ..:|:.:
Human   442 QKRGRTEFEKEPR-TDTNSSPSRASVCGIFVDFASASHRQKSRTQALKQKMRSTKLLRLIDLDFS 505

  Fly   262 ------------IYDSYMENFAES--------------QKDGTKKEERKR--------------G 286
                        .||.|:.||.:.              ::|...:|...|              |
Human   506 FTFSLLDLPPVNEYDMYIRNFGKKNTKQAYVQCNEDNVERDIQTEEIETREVWTQHPGESTVVSG 570

  Fly   287 KREKKFRDKSAIAEQLNKKYL------KCWQILERMINQNIYDDIAHDYRYW----EDPADEFRE 341
            ..|::....:.:..:::...|      .| |::..::.:   |.:|.: ..|    :|.|..|.:
Human   571 GSEQRDTSDAVVMPKIDTPRLCSFLRAAC-QVMAVLLEE---DRLAAE-PSWNLRAQDRALYFSD 630

  Fly   342 GEGNL---LPLWKFQYDKTKKMNVTDI--LFNPSYYDLFAVCFGSHDFMKQTNEGY-LCLFTVKN 400
            ....|   ||.  .|..|...::.:.:  ....|.:||     ....|:...:..| ||::.:..
Human   631 SSSQLNTSLPF--LQNRKVSSLHTSRVQRQMVVSVHDL-----PEKSFVPLLDSKYVLCVWDIWQ 688

  Fly   401 PSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCK------------------- 446
            ||.|..::..:..|.||.:.|...||...|...|:|.|::||||.:
Human   689 PSGPQKVLICESQVTCCCLSPLKAFLLFAGTAHGSVVVWDLREDSRLHYSVTLSDGFWTFRTATF 753

  Fly   447 ------------------EPLYVSRGVNCKHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWIL 493
                              ||  :|..|:.|....:.......:|:....:..|:...|.:..|::
Human   754 STDGILTSVNHRSPLQAVEP--ISTSVHKKQSFVLSPFSTQEEMSGLSFHIASLDESGVLNVWVV 816

  Fly   494 MQNKLWVTTIITLYRENGLVDGPD-----------------------GTKVTLKSGGSCMVFHPV 535
            ::  |....|.....:.||:.|..                       ||..||.     :.|.|.
Human   817 VE--LPKADIAGSISDLGLMPGGRVKLVHSALIQLGDSLSHKGNEFWGTTQTLN-----VKFLPS 874

  Fly   536 DNKIFLVGTECGYI---YKCSTAFSSKYLMTYYAHN---MSVYRIDFNRFNSNIFVSCGADWMVK 594
            |...|::||:.|.|   .:.....:.| |.....|.   :.|..|||:.|...||::..:|..::
Human   875 DPNHFIIGTDMGLISHGTRQDLRVAPK-LFKPQQHGIRPVKVNVIDFSPFGEPIFLAGCSDGSIR 938

  Fly   595 VWEDMRPDPLFIFDLGA---AVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPK 656
            :.:.....||..:|...   ||..::|:|....||........::::||..:....:..|.|.|.
Human   939 LHQLSSAFPLLQWDSSTDSHAVTGLQWSPTRPAVFLVQDDTSNIYIWDLLQSDLGPVAKQQVSPN 1003

  Fly   657 RKNKLTRLSFNEK-----LAFIVVGDEKGVTTSLKLSPNLRMMVKPPKKQLYLDQNTLQIGKLEK 716
            |...:..:...||     ||.::.    ..:.|:.:....|....|            ::.:..:
Human  1004 RLVAMAAVGEPEKAGGSFLALVLA----RASGSIDIQHLKRRWAAP------------EVDECNR 1052

  Fly   717 LLSLVREL--PEG 727
            |..|::|.  |||
Human  1053 LRLLLQEALWPEG 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	85/429 (20%)
		WD40 repeat	362..412	CDD:293791	10/52 (19%)
		WD40	413..640	CDD:295369	60/295 (20%)
		WD40 repeat	415..454	CDD:293791	16/75 (21%)
		WD40 repeat	463..505	CDD:293791	6/41 (15%)
		WD40 repeat	513..557	CDD:293791	13/69 (19%)
		WD40 repeat	571..608	CDD:293791	10/36 (28%)
		WD40 repeat	613..654	CDD:293791	8/40 (20%)
DYNC2I1	XP_006716104.1	WD40	630..1020	CDD:225201	83/406 (20%)
		WD40 repeat	648..676	CDD:293791	4/32 (13%)
		WD40 repeat	736..778	CDD:293791	3/43 (7%)
		WD40 repeat	785..814	CDD:293791	3/28 (11%)
		WD40 repeat	829..860	CDD:293791	3/30 (10%)
		WD40	<915..987	CDD:295369	17/71 (24%)
		WD40 repeat	916..952	CDD:293791	9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810