DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and dync2i2

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_012823678.1	Gene:	dync2i2 / 448417	XenbaseID:	XB-GENE-953027	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	457	Identity:	114/457 - (24%)
Similarity:	195/457 - (42%)	Gaps:	87/457 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 ILERMINQNIYDDIAHDYRY-WEDPADEFREGEGNLLPLWKFQYDKT--KKMNVTDILFNPSYYD 373
            |:.:.:|:|........|.. ||:..::       :..|...||...  :::.||.:.:|.:  .
Frog    85 IMIKELNKNWKSHAFDGYEVNWEEQHEQ-------VTCLHSLQYPDALEQQLQVTSVSWNST--G 140

  Fly   374 LFAVC----FGSHDFMKQTNEGYLCLFTVKNPSF----PDYIIQTDCGVMCCDIHPTYPFLAVIG 430
            ....|    ||..|:  .|.:.|:|.:.:....|    ||.::.....|||...||:.|.|...|
Frog   141 SIIACSYGRFGDGDW--STEKSYVCTWNLDRRGFNANNPDTVLDVPSSVMCLAWHPSQPSLIAGG 203

  Fly   431 LYDGNVAVYNL-REDCKEPLYVSRG-VNCKHGECVWQIKWGLDMADGEVN-FFSVSSDGRVFNWI 492
            |::|:|.|::. |.|  :||....| |...|.:.|:|:.|..:.:.|..: .|||||||::..|
Frog   204 LFNGDVLVWDTSRTD--DPLIGRTGHVGDTHTDAVYQVGWMQEKSQGHRHQVFSVSSDGKILVW- 265

  Fly   493 LMQNKLWVTTIITLYRENGLV--DG--------PDGTKVTLKSGG------SCMVFHPVDNKIFL 541
                        .:.:|..||  ||        |..||:.....|      :|:.:...|..:|:
Frog   266 ------------QMEKEGHLVLLDGFALVAQQIPSNTKIHKPGRGDTAVGVTCLSYSHFDPSLFI 318

  Fly   542 VGTECGYIYKCSTAF---------SSKYL-----MTYYAHNMSVYRIDFNRFNSNIFVSCGADWM 592
            ||.|.||:.|||::.         ||..|     .|:..|...||.:..:.|:.|:|:|.|.|..
Frog   319 VGVEGGYLLKCSSSVQTLAPINMGSSVPLRAPAQFTFSPHGGPVYSVTCSPFHRNLFLSAGTDGH 383

  Fly   593 VKVWEDMRPDPLFIFDLGAA-VGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYK-AICIQAVVP 655
            ..::..::..||....|... :..::|:|....||||.:.:|:|.:.|...:..| ::||:....
Frog   384 AHLYSMLQAKPLVSLQLSQKYLFSIRWSPVRPLVFAAASGDGEVVLVDFAKSFQKPSLCIKQTAS 448

  Fly   656 KRKNKLTRLSFNE-KLAFIVVGDEKGVTTSLKLSPNLRMMVKPPKKQLYLDQNTLQIGKLEKLLS 719
            .|  .:..|.||. :...:..||..|.....:||.:            :::|...:...|:::.|
Frog   449 GR--PVYCLEFNHAQSQLLAAGDGTGTVKIWQLSSD------------FIEQRARETALLDEIAS 499

  Fly   720 LV 721
            .|
Frog   500 EV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	103/398 (26%)
		WD40 repeat	362..412	CDD:293791	13/57 (23%)
		WD40	413..640	CDD:295369	75/260 (29%)
		WD40 repeat	415..454	CDD:293791	15/39 (38%)
		WD40 repeat	463..505	CDD:293791	12/42 (29%)
		WD40 repeat	513..557	CDD:293791	18/68 (26%)
		WD40 repeat	571..608	CDD:293791	10/36 (28%)
		WD40 repeat	613..654	CDD:293791	12/41 (29%)
dync2i2	XP_012823678.1	WD40 repeat	131..182	CDD:293791	13/54 (24%)
		WD40	184..481	CDD:392136	87/313 (28%)
		WD40 repeat	188..227	CDD:293791	15/40 (38%)
		WD40 repeat	236..297	CDD:293791	20/73 (27%)
		WD40 repeat	305..355	CDD:293791	14/49 (29%)
		WD40 repeat	362..399	CDD:293791	10/36 (28%)
		WD40 repeat	405..446	CDD:293791	12/40 (30%)
		WD40 repeat	452..477	CDD:293791	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6637
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940