DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9313 and CG14838

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster

Alignment Length:	788	Identity:	142/788 - (18%)
Similarity:	243/788 - (30%)	Gaps:	302/788 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 YPLPMPNYTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVE---DEDVEEEDDEEAKGTEGDEGE 189
            ||:.||.:...:.|.|.:|                :|..:|   :|:::.|:
  Fly   227 YPIQMPRHVAFDYRMTRDV----------------RDGVLELLPNENIKWEN------------- 262

  Fly   190 GEGEGEGAAARQEDDEPAHQAAAVSSKKRKLINQFNYCERGALTYTNPKRNVDTQTIPP--PRSQ 252
                                    .:|||.                    ||..|:.||  .|.|
  Fly   263 ------------------------VTKKRV--------------------NVSVQSAPPKIEREQ 283

  Fly   253 -----FGANVLQWVIYDSYMENFAESQKDGTKKEERKRGKR--------EKKFRDKSAIAEQLNK 304
                 |.:|.....:|:...|:....:.|..::||:|:.:.        |||..:.||..|
  Fly   284 QTNPTFPSNAWSQYLYEIDDEDLELDETDVDEEEEKKKAQAKPGTYVEPEKKPPEMSAQIE---- 344

  Fly   305 KYLKCWQILERMINQNIYDDIAHDY---------RYWEDPADEFREGEGNLLPLWKFQYDKTKKM 360
                   :|...:..|..|....||         :|......||         |......|:.|.
  Fly   345 -------MLLNTLEFNQIDSYRDDYSLISSRQVVQYTNPYLQEF---------LCFANISKSNKR 393

  Fly   361 NVTDILFNPSYYDLFAVCFGSHDFM------KQTNE-GYLCLFTVK-NP----SFPDYI------ 407
            .|....:.|....|.||   |:.|.      :.||. .|:....:: ||    ||.|.:
  Fly   394 FVAGYDWYPKLSGLIAV---SYAFSTPATVNEATNRVDYVQRAVLEPNPVLLWSFSDNLNYKLEF 455

  Fly   408 ---IQTDCGVMCCDIHPTYPF---LAVIGLYDGNVAVYNLREDCK---EPLYVSRGVNCKHGECV 463
               |:|.....|       ||   :.:.|..:|.|.:::|:..|:   |..|:: ....|:...:
  Fly   456 EAPIETTALTFC-------PFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLT-AAQAKYRIMI 512

  Fly   464 WQ-IKWGLDMAD----------------GEVNFF-------SVSSDGRVFN--WILMQNKLWVTT 502
            .: :.|.:|:.|                |.:..|       .:|..|:|:|  .|...:|.:||.
  Fly   513 GEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFVTC 577

  Fly   503 IITLYRENGLV-----DGPDGTKVTLK--------------SGGSCMVFHPVDNKIF-------L 541
            ..     :|.:     ||..|.....|              |....||..|..|..|       :
  Fly   578 AF-----DGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITGII 637

  Fly   542 VGTECGYIYKCST-------AFSSKY-----------------LMTYYAHNMSVYRIDF------ 576
            ..|.|   ..|.|       |..|.|                 :.|:|.|   |.|||:
  Fly   638 ADTSC---LSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGH---VSRIDWQGTYTE 696

  Fly   577 --------------------------NRFNSNIFVSCGADWMVKVW-EDMRPDPLFIFDLGAAVG 614
                                      |.|...:|.|.|.. ::.:| ||....|:|.......:.
  Fly   697 GEATEVINSSIPFAMVHDGPVVMVKKNPFYPELFASIGRT-ILAIWKEDYNYSPIFWRKRACDLT 760

  Fly   615 DVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVV------------PKRKNKLTRL-SF 666
            .|.|:.....|......:|.:..:|:......| |:..::            |...:|:..: .:
  Fly   761 AVAWSETRPAVLYLTRIDGILEAWDILARDDDA-CLTEILGGGIITAITEHRPSLPHKILGIGDY 824

  Fly   667 NEKLAFIVVGDEKGVTTSLKLSPNLRMMVKPPKKQLYLDQNTLQIGKLEKLLSLVRELPEGSTAV 731
            |..:..:.:.....|....:|...::.::|..::::.:....      :|...|.:::.|   |.
  Fly   825 NSSIRMVKLPHSFDVPLPNELDQLIKYVLKEERRKMGIQSWE------QKYYELNKDIIE---AK 880

  Fly   732 PDAATTVR 739
            .:||..:|
  Fly   881 REAAAEIR 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	91/501 (18%)
		WD40 repeat	362..412	CDD:293791	17/70 (24%)
		WD40	413..640	CDD:295369	63/341 (18%)
		WD40 repeat	415..454	CDD:293791	10/44 (23%)
		WD40 repeat	463..505	CDD:293791	13/67 (19%)
		WD40 repeat	513..557	CDD:293791	15/76 (20%)
		WD40 repeat	571..608	CDD:293791	14/69 (20%)
		WD40 repeat	613..654	CDD:293791	7/40 (18%)
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	62/306 (20%)
		WD40 repeat	462..505	CDD:293791	10/50 (20%)
		WD40 repeat	510..547	CDD:293791	4/36 (11%)
		RE_R_Pab1	807..>863	CDD:286594	6/55 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840