DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9313 and CG15701

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_611100.1	Gene:	CG15701 / 36801	FlyBaseID:	FBgn0034095	Length:	1051	Species:	Drosophila melanogaster

Alignment Length:	665	Identity:	135/665 - (20%)
Similarity:	217/665 - (32%)	Gaps:	227/665 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PGKGDGKQVKGKLRTSKNKTDGPGGGGGDADDFDAWMKSRQLLKPDDQLDLTEAELGEEITKVLT 69
            |.|||.:.|..:.||.....|               .:...:||.:.....:|.|.
  Fly   177 PSKGDARIVPARSRTYTRTLD---------------PEEVVILKRESAKQRSEVEA--------- 217

  Fly    70 PTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAFAGNSLHVDSDEGRRQIEESDEIGYPLPMPN 134
                           ||.|.|..|        :||     .|..||.::...|||.  |.....:
  Fly   218 ---------------KESEPVKQP--------VAF-----EVKFDEAKKPEPESDH--YSDDFES 252

  Fly   135 YTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDVEEED---------------DEEAKGTE 184
            |.  ...|||....:|.|.:|..: .::.:|.||:|. ||||               |:|.|...
  Fly   253 YE--SDFETDASTPDEVESDEAQE-PSSSEAEVEEER-EEEDSEPTQNPITVIQRDKDQERKLDS 313

  Fly   185 G---------------DEGEGEGEGEGAAARQED----------DEPAHQAA------------- 211
            |               .:.:.:.....:.|..|.          ::|....|
  Fly   314 GHYDMHLRRNPLSSLSTQNQYDSFDTNSMANSEQLDSGISTTGVEKPRSGEANVYYGGYSGFVSH 378

  Fly   212 -AVSSKKRKLI-----NQFNY--CERGALTY-------------------TNPKRNVDTQTIP-- 247
             .:|.:..:|:     :|.||  .|...|:|                   .:|..:.:.||:.
  Fly   379 PVISRRGEELMAKLRFDQLNYHLFEMKPLSYEGFMQSYGKLNASQVATQTQSPHMDGECQTLEVH 443

  Fly   248 --------PPRSQFGANVLQWVIYDSYMENFAES-QKDGTKKEERKRGKREKKFRDKSAIAEQLN 303
                    ||  .:|.   |:|:..|......|: .|....:.|....:.|:..|.:.|.::||.
  Fly   444 SRSSWTQHPP--HYGG---QFVLSCSVDAELDETWSKQPADEYEASISRLEQLHRLEQARSQQLQ 503

  Fly   304 KKYLKCWQILERMINQNIY------------DDIAHDYRYWEDPADEFREGEGNL---LPLWKFQ 353
            :|.|.....||| :|..::            ...||              |:||.   :||
  Fly   504 QKRLAKSTDLER-LNSFLHRAGRLMGLVLEGKTTAH--------------GQGNSPRNVPL---- 549

  Fly   354 YDKTKKMNVTDI--LFNPSYYDLFAV----CFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDC 412
              :|..:|...:  :|..:......|    |....:..|:.....|.::::.|||.|..::.|..
  Fly   550 --QTGLLNALPVRRIFGSAGNGQLVVTVHECPADSNVYKEDFASLLMVWSLANPSQPLRLLSTWA 612

  Fly   413 GVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLYVSR-GVNCKHGECVWQIKWGLDMADGE 476
            .|....:......:.|.||.||:||:::|||...   |.|: ..:..|......:....:..|.|
  Fly   613 EVSRVALSAQAQDIVVAGLRDGSVAMWDLRETHS---YCSKLDGHLTHFAATQSVVPMPEQQDKE 674

  Fly   477 VNFFSVSS--DGRVFNWILMQNKLWVTT-IITLYRE--------NG------LVDGPDGT----- 519
            ||...:.:  |.|.|...|....:..|: :.|.|:|        :|      ||:|...|
  Fly   675 VNAMDLGAVVDVRSFRSHLNAGGVAATSGLQTTYKEVQYASLNDSGLLTMWTLVEGASSTNSNEF 739

  Fly   520 -----KVTLKSGGSC 529
                 :|.|...|||
  Fly   740 SSPWARVKLLQSGSC 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	48/211 (23%)
		WD40 repeat	362..412	CDD:293791	10/55 (18%)
		WD40	413..640	CDD:295369	36/145 (25%)
		WD40 repeat	415..454	CDD:293791	12/39 (31%)
		WD40 repeat	463..505	CDD:293791	9/44 (20%)
		WD40 repeat	513..557	CDD:293791	8/27 (30%)
		WD40 repeat	571..608	CDD:293791
		WD40 repeat	613..654	CDD:293791
CG15701	NP_611100.1	PTZ00108	<23..270	CDD:240271	32/148 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910