DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and Dnai4

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001019957.1	Gene:	Dnai4 / 313417	RGDID:	1311027	Length:	803	Species:	Rattus norvegicus

Alignment Length:	814	Identity:	198/814 - (24%)
Similarity:	320/814 - (39%)	Gaps:	202/814 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TDGPGGGGGDADDFDAWMKSRQL-----LKPDDQLDLTEAELGEEITKVLTPTNTNIVRNLVVYS 83
            |.|.|..|.:.....|   ||.:     :||.::|::..|:|    .:||.|...::
  Rat    34 TGGKGYAGANQSKIVA---SRTMTFLPEMKPAEKLNIASAKL----VQVLDPRGVDV-------- 83

  Fly    84 FKEGEFVPAPL-----------PGNTVTLIAFAGNSLHVDSDEGRRQIEESDEIG---------Y 128
                  .|.||           |...:|            |.||..   .||.|.         .
  Rat    84 ------TPRPLYHPDPHAMPTKPSKLLT------------SQEGSM---GSDYISSYSLYQNTLN 127

  Fly   129 PLPMPNYT--VVEQRET---DNVDGEEGEGEEDDDGATAKD----------------AAVEDEDV 172
            |..:..||  |:....|   .::...|...|:.:|.:..:|                ||:..|::
  Rat   128 PSMLGQYTRSVIGSSSTVSKSSISTTESMTEDLEDPSYKRDRLASFADVRVMRAPAEAAITKEEL 192

  Fly   173 EEEDDEEAKGTEGDEGEGEGEGEGAAARQEDDEPAHQAAAVSSKKRKLINQ-FNY---C------ 227
            |...:.....||              ..:..|.|....:..|.:..|:|.: .||   |
  Rat   193 ERNVEIFLMETE--------------TLRFFDLPTVMISTDSEEAEKVIEKNINYEILCRNRLGN 243

  Fly   228 ----ERGALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSYMENFAESQKDGTKKEERKRGK- 287
                ||...|:....:|.|.|.......:.|.....|.:|||:  |..|:.....:.....:..
  Rat   244 DLYVERMMQTFNGAPKNKDVQCDKIIMEEKGVMATTWDLYDSF--NIPEASLAAKRSAYLSKASL 306

  Fly   288 ----REKKFRDKSAIA----------------EQLNKKYLKCWQI------LERMINQNIYDDIA 326
                |:.|.:|..:.:                |..::|.||..::      :||::.:|::....
  Rat   307 LVRDRDPKIQDSESSSLMDIESVILAKSHEDEEDNSEKILKSDKLHQDLFYMERVLMENVFQPKL 371

  Fly   327 HDYR----YWE-DPA--------------DEFREGE--------------------GNLLPLWKF 352
            ..||    |.| :|.              ||.::.|                    .||..||.|
  Rat   372 AAYRQLPIYKELEPGQPEEDLQVVNKVTEDEVKKDEEEEMETELEIEITTEQSTIPANLERLWSF 436

  Fly   353 QYDKTKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCC 417
            ..|.||.:||:.:.:|.:..||.||.:|:..| |:...|..|.:::|||.:|:.|.|:..||...
  Rat   437 SCDLTKGLNVSSLSWNKANSDLLAVGYGNFGF-KEQKRGMACCWSIKNPMWPERIYQSPYGVTSV 500

  Fly   418 DIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLYVSRGVNCKHGECVWQIKW-----GLDMADGEV 477
            |...:.|.|..:|.::|.||:||::.:...|:..|.....||...|||::|     |....|...
  Rat   501 DFSISSPNLLAVGYHNGTVAIYNVQSNHNTPVLDSSESPQKHLGPVWQVQWIEQDRGTTGDDRRE 565

  Fly   478 NFFSVSSDGRVFNWILMQN-------KLWVTTIITLYRENGLVDGPDG-TKVTLKSGGSCMVFHP 534
            ...|:|:|||:..|::.:.       .|..||:.:  .:.|:.....| ..::.::.|.|..||.
  Rat   566 ILVSISADGRISKWVIRKGLDCHDLMHLKRTTVTS--SKKGIEKEKKGEALISRQAPGMCFAFHT 628

  Fly   535 VDNKIFLVGTECGYIYKCSTAFSSKYLMTYYAHNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDM 599
            .|..|:|.|||.|.|:|||.:::.:||.||..|...||::.:|.|..::|:||.|||.|.:|...
  Rat   629 KDTNIYLAGTEEGLIHKCSCSYNEQYLETYRGHKGPVYKVTWNPFCPDVFLSCSADWGVMIWHQD 693

  Fly   600 RPDPLFIF-DLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKRKNKLTR 663
            ...|.|.| .....|.||.|:|.|:.:||| ..|.:|.::||.::....:.:....|  ..|.|.
  Rat   694 NVKPFFTFYPTTYVVYDVAWSPKSAYIFAA-ANENRVEIWDLQISTLDPLIVNVANP--GIKFTT 755

  Fly   664 LSFNEKLAFIVVGDEKGVTTSLKLSPNLRMMVKP 697
            :.|.::...::|||..|.....:    ||.|..|
  Rat   756 VLFAKQTDCLLVGDSDGQVAVYE----LRNMPTP 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	113/359 (31%)
		WD40 repeat	362..412	CDD:293791	17/49 (35%)
		WD40	413..640	CDD:295369	78/240 (33%)
		WD40 repeat	415..454	CDD:293791	11/38 (29%)
		WD40 repeat	463..505	CDD:293791	15/53 (28%)
		WD40 repeat	513..557	CDD:293791	16/44 (36%)
		WD40 repeat	571..608	CDD:293791	15/37 (41%)
		WD40 repeat	613..654	CDD:293791	13/40 (33%)
Dnai4	NP_001019957.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..109		4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..163		3/19 (16%)
		WD40	<443..781	CDD:225201	107/347 (31%)
		WD40 repeat	447..492	CDD:293791	15/45 (33%)
		WD 1. /evidence=ECO:0000255	492..532		12/39 (31%)
		WD40	496..778	CDD:295369	88/286 (31%)
		WD40 repeat	497..541	CDD:293791	12/43 (28%)
		WD 2. /evidence=ECO:0000255	541..589		14/47 (30%)
		WD40 repeat	547..616	CDD:293791	16/70 (23%)
		WD 3. /evidence=ECO:0000255	616..656		16/39 (41%)
		WD40 repeat	621..659	CDD:293791	18/37 (49%)
		WD 4. /evidence=ECO:0000255	660..700		14/39 (36%)
		WD40 repeat	666..701	CDD:293791	13/34 (38%)
		WD 5. /evidence=ECO:0000255	703..742		13/39 (33%)
		WD40 repeat	708..740	CDD:293791	13/32 (41%)
		WD 6. /evidence=ECO:0000255	748..787		12/44 (27%)
		WD40 repeat	750..779	CDD:293791	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44552
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920