DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and Dync2i2

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001005542.2	Gene:	Dync2i2 / 296618	RGDID:	1359465	Length:	537	Species:	Rattus norvegicus

Alignment Length:	627	Identity:	144/627 - (22%)
Similarity:	236/627 - (37%)	Gaps:	142/627 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PLPMPNYTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDVEEED-DEEAKGTEGDEGE--- 189
            |.|.|.  |...|......|..|.||.     ..:.|.::||.:.... ..:.:..:|..||
  Rat     7 PRPFPR--VGSARVAALAAGGAGGGER-----RGRPAPLQDETLGVASVPSQWRSVQGIRGEPKS 64

  Fly   190 ----GEGEGEGAA-ARQEDD-----EPAHQAAAVSSKKRKLINQFNYCERGALTYTNPKRNVDTQ 244
                |....|.:| ||...|     |...:.|||:.     ::|::.....|..     |.|:..
  Rat    65 CQTAGIATAEASAQARTHADAQVQTEAPEEPAAVAP-----VSQYDTLRLAAFL-----RRVEAM 119

  Fly   245 TIPPPRSQFGANVLQWVIYDSYMENFAESQKDGTKKEERKRGKREKKFRDKSAIAEQLNKKYLKC 309
            .:....:.:.::.     :|.|..|:.|.|:.                              :.|
  Rat   120 VVRELNNNWQSHA-----FDGYEVNWTEQQQT------------------------------VSC 149

  Fly   310 WQILERMINQNIYDDIAHDYRYWEDPADEFREGEGNLLPLWKFQYDKTKKMNVTDILFNPSYYDL 374
                            .|...|  .||    :|:|               ::||.|.:|.: ..:
  Rat   150 ----------------LHTLGY--PPA----QGQG---------------LHVTGISWNTT-GSV 176

  Fly   375 FAVCFGS-HDFMKQTNEGYLCLFTVK----NPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDG 434
            .|..:|. .|....|.:.|:|.:.:.    ||..|..:::....|||...||..|.....|||.|
  Rat   177 LACAYGRLDDGDWGTLKSYVCTWNLDRQGLNPHQPSVVVEVPSAVMCLAFHPIQPSHIAGGLYSG 241

  Fly   435 NVAVYNLREDCKEPLYVSRGV-NCKHGECVWQIKWGLDMADG-EVNFFSVSSDGRVFNW------ 491
            .|.|:::... ::||....|: :..|.:.|:|:.|..:.... .....|.::||||..|
  Rat   242 EVLVWDMSRP-EDPLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGRVLLWRGSGAG 305

  Fly   492 ILMQNKLWVTTIITLYRENGLVDGPDG-TKVTLKSGGSCMVFHPVDNKIFLVGTECGYIYKCSTA 555
            .|..:|.:...:..|.|...|...|.| |:|    |.:.:.|...|:.:|::|||.|:..|||.|
  Rat   306 QLRLSKGFALAVQQLPRSTKLKKPPRGETEV----GVTSVAFSSFDSSLFVLGTEGGFPLKCSLA 366

  Fly   556 FSSKYL--------------MTYYAHNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFI 606
            ..:..|              .|:..|...||.:..:.|:.|:|:|.|.|..|.::..::..||..
  Rat   367 AEAAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTS 431

  Fly   607 FDLG-AAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKRKNKLTRLSFN-EK 669
            ..|. ..:..|:|:|....||||.:.||.|.:|||..:..|. .:.....:..:.:..|.|| ::
  Rat   432 LQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKP-TVSITQTQDGSPVYCLEFNSQQ 495

  Fly   670 LAFIVVGDEKGVTTSLKLSPNLRMMVKPPKKQLYLDQNTLQI 711
            ...:..||.|||....:||  .....:.|::...|||...:|
  Rat   496 TQLLAAGDAKGVVKVWQLS--TAFTEQGPREAEDLDQLEAEI 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	100/382 (26%)
		WD40 repeat	362..412	CDD:293791	13/54 (24%)
		WD40	413..640	CDD:295369	72/250 (29%)
		WD40 repeat	415..454	CDD:293791	13/38 (34%)
		WD40 repeat	463..505	CDD:293791	11/48 (23%)
		WD40 repeat	513..557	CDD:293791	16/44 (36%)
		WD40 repeat	571..608	CDD:293791	11/36 (31%)
		WD40 repeat	613..654	CDD:293791	14/40 (35%)
Dync2i2	NP_001005542.2	WD40	101..515	CDD:225201	114/499 (23%)
		WD40 repeat	165..211	CDD:293791	12/46 (26%)
		WD40	218..515	CDD:295369	85/304 (28%)
		WD40 repeat	223..265	CDD:293791	13/42 (31%)
		WD40 repeat	271..309	CDD:293791	9/37 (24%)
		WD40 repeat	339..389	CDD:293791	12/49 (24%)
		WD40 repeat	396..433	CDD:293791	11/36 (31%)
		WD40 repeat	439..479	CDD:293791	14/40 (35%)
		WD40 repeat	486..511	CDD:293791	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810