DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9313 and DYNC1I1

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_004402.1	Gene:	DYNC1I1 / 1780	HGNCID:	2963	Length:	645	Species:	Homo sapiens

Alignment Length:	608	Identity:	127/608 - (20%)
Similarity:	241/608 - (39%)	Gaps:	112/608 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 EEGEGEEDDDGATAKDAAVEDEDVEEEDDE----------------------------------- 178
            ||...:::.|....|:...:|.|::.:..|
Human    29 EEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVP 93

  Fly   179 -------EAKGTEGDEGEGEGEGEGAAAR--QEDDEPA-HQAAAVSSKKRKL-------INQFNY 226
                   ::..|..:.|..:....|...|  |.|.:|: .|..:.|...|:|       :.|.::
Human    94 TPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDF 158

  Fly   227 CERGALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSYMENFAESQKDGTKKEERKRGKREKK 291
            ..|..::|:.     :||| |....|...:.....:.:|.:...:|.:....|:|.::...||..
Human   159 LPREVVSYSK-----ETQT-PLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEVKEAPPRELT 217

  Fly   292 FRDKSAI--AEQLNKKYLKCWQILERMINQNIYDDIAHDYRYWEDPADEFREGEGNL-----LPL 349
            ..:|..|  :|:....:.:..:::||.:.::  .||..||     ...|..|.:|::     |..
Human   218 EEEKQQILHSEEFLIFFDRTIRVIERALAED--SDIFFDY-----SGRELEEKDGDVQAGANLSF 275

  Fly   350 WKFQYDK--TKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVK-NPSFPDYIIQTD 411
            .:..||:  :|...||.:.::..|.:|....:.:::......:|...::.:| ..:.|:|:....
Human   276 NRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQ 340

  Fly   412 CGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLY---VSRGVNCKHGECVWQIKWGLDMA 473
            ..||.......:|.|.|.|.|.|.:.:::.|...:.|:.   :|...:.....||..:  |...|
Human   341 SSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVV--GTQNA 403

  Fly   474 DGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNK 538
            .   |..:||:||::.:|.|........::..:|.:         :|....:|   |.|...|..
Human   404 H---NLITVSTDGKMCSWSLDMLSTPQESMELVYNK---------SKPVAVTG---MAFPTGDVN 453

  Fly   539 IFLVGTECGYIY-KCSTAFSSKYLMTYYAH---------NMSVYRIDFNRFNSNIFVSCGADWMV 593
            .|:||:|.|.:| .|.....:.....:..|         :|:|..|||    |::||:...||.|
Human   454 NFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDF----SHLFVTSSFDWTV 514

  Fly   594 KVWEDMRPDPLFIFDLGA-AVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKR 657
            |:|......||:.|:..| .|.||.|:|....:||.|...|::.::  |:|....:...:|..:.
Human   515 KLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLW--NLNNDTEVPTASVAIEG 577

  Fly   658 KNKLTRLSFNEKLAFIVVGDEKG 680
            .:.|.|:.:.:....:.|||.:|
Human   578 ASALNRVRWAQAGKEVAVGDSEG 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	82/345 (24%)
		WD40 repeat	362..412	CDD:293791	8/50 (16%)
		WD40	413..640	CDD:295369	62/240 (26%)
		WD40 repeat	415..454	CDD:293791	10/41 (24%)
		WD40 repeat	463..505	CDD:293791	10/41 (24%)
		WD40 repeat	513..557	CDD:293791	12/44 (27%)
		WD40 repeat	571..608	CDD:293791	14/36 (39%)
		WD40 repeat	613..654	CDD:293791	11/40 (28%)
DYNC1I1	NP_004402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		6/28 (21%)
		Interaction with DCTN1. /evidence=ECO:0000250	2..123		10/93 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..125		4/29 (14%)
		Dynein_IC2	147..173	CDD:371592	6/31 (19%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	147..163		2/15 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..221		11/52 (21%)
		WD40	283..606	CDD:392136	80/341 (23%)
		WD 1	285..334		7/48 (15%)
		WD40 repeat	291..337	CDD:293791	7/45 (16%)
		WD 2	338..378		9/39 (23%)
		WD40 repeat	346..385	CDD:293791	8/38 (21%)
		WD 3	387..428		11/45 (24%)
		WD40 repeat	393..434	CDD:293791	11/45 (24%)
		WD 4	437..477		12/42 (29%)
		WD40 repeat	442..481	CDD:293791	11/41 (27%)
		WD 5	482..527		16/48 (33%)
		WD40 repeat	488..529	CDD:293791	15/44 (34%)
		WD 6	530..570		12/41 (29%)
		WD40 repeat	535..573	CDD:293791	11/39 (28%)
		WD 7	576..615		6/25 (24%)
		WD40 repeat	581..607	CDD:293791	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810