DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and Dync1i2

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001185801.1	Gene:	Dync1i2 / 13427	MGIID:	107750	Length:	655	Species:	Mus musculus

Alignment Length:	666	Identity:	140/666 - (21%)
Similarity:	251/666 - (37%)	Gaps:	162/666 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 IEESDEIGYPLPMPNYTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDVEEEDDEEAKGTE 184
            :.:..::...|......:.:.||......||.:.:|.|.   .|:|||   .|:||.|.|.|..|
Mouse     1 MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKETDQ---KKEAAV---SVQEESDLEKKRRE 59

  Fly   185 GD-----------------------------------------------------EGEGEGEGEG 196
            .:                                                     |...:..|:|
Mouse    60 AEALLQSMGLTTDSPIGFLLSEDSSFNQVDIKLVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDG 124

  Fly   197 AAARQE---DDEPA----HQAAAVSSKKRKL----INQFNYCERGALTYTNPKRNVDTQTIPPPR 250
            |...:.   |.:|:    |..:.:.....||    |.|.::..|..:|||   :...|.....|:
Mouse   125 AVGSRTLHWDTDPSVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYT---KETQTPVTAQPK 186

  Fly   251 SQFGANVLQWVIYDSYMENFAESQKDGTKKEERKRGKREKKFRDKSAIAEQL----------NKK 305
            .            |...|:...:.|...:.||.|..|:::: .|..|...:|          :::
Mouse   187 E------------DEEEEDDVATPKPPVEPEEEKTLKKDEE-NDSKAPPHELTEEEKQQILHSEE 238

  Fly   306 YLKCW----QILERMINQNIYDDIAHDY--RYWEDPADEFREGE---GNLLPLWKFQYDK--TKK 359
            :|..:    :|:||.:::.|  :|..||  |..||     :|||   |..|.|.:..:|:  :|.
Mouse   239 FLSFFDHSTRIVERALSEQI--NIFFDYSGRDLED-----KEGEIQAGAKLSLNRQFFDERWSKH 296

  Fly   360 MNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVK-NPSFPDYIIQTDCGVMCCDIHPTY 423
            ..|:.:.::..|.:|....:.:::......:|...::.:| ..:.|:|:......||.......:
Mouse   297 RVVSCLDWSSQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFH 361

  Fly   424 PFLAVIGLYDGNVAVYNLREDCKEPLY---VSRGVNCKHGECVWQIKWGLDMADGEVNFFSVSSD 485
            |.|.|.|.|.|.:.:::.|.:.:.|:.   :|...:.....||..:  |...|.   |..|:|:|
Mouse   362 PNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVV--GTQNAH---NLISISTD 421

  Fly   486 GRVFNWILMQNKLWVTTIITLYRENGLVDGP-DGTKVTLKSGG----SCMVFHPVDNKIFLVGTE 545
            |::.:|.|                 .::..| |..::..|...    :.|.|...|...|:||:|
Mouse   422 GKICSWSL-----------------DMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSE 469

  Fly   546 CGYIY-KCSTAFSSKYLMTYYAH---------NMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMR 600
            .|.:| .|.....:.....:..|         :.:|..:||    |::||:...||.||:|....
Mouse   470 EGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDF----SHLFVTSSFDWTVKLWTTKN 530

  Fly   601 PDPLFIF-DLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKRKNKLTRL 664
            ..||:.| |....|.||.|:|....:||.|...|::.::  |:|....:...::..:....|.|:
Mouse   531 NKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLW--NLNNDTEVPTASISVEGNPALNRV 593

  Fly   665 SFNEKLAFIVVGDEKG 680
            .:......|.|||.:|
Mouse   594 RWTHSGREIAVGDSEG 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	78/350 (22%)
		WD40 repeat	362..412	CDD:293791	7/50 (14%)
		WD40	413..640	CDD:295369	60/245 (24%)
		WD40 repeat	415..454	CDD:293791	10/41 (24%)
		WD40 repeat	463..505	CDD:293791	10/41 (24%)
		WD40 repeat	513..557	CDD:293791	13/49 (27%)
		WD40 repeat	571..608	CDD:293791	14/37 (38%)
		WD40 repeat	613..654	CDD:293791	11/40 (28%)
Dync1i2	NP_001185801.1	Dynein_IC2	152..180	CDD:288403	8/30 (27%)
		WD40 repeat	299..348	CDD:293791	7/48 (15%)
		WD40	346..>616	CDD:225201	69/292 (24%)
		WD40 repeat	356..394	CDD:293791	8/37 (22%)
		WD40	397..>622	CDD:295369	58/241 (24%)
		WD40 repeat	402..443	CDD:293791	13/62 (21%)
		WD40 repeat	451..498	CDD:293791	11/46 (24%)
		WD40 repeat	506..538	CDD:293791	12/35 (34%)
		WD40 repeat	544..582	CDD:293791	11/39 (28%)
		WD40 repeat	590..616	CDD:293791	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810