DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and Dync1i1

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_006505045.1	Gene:	Dync1i1 / 13426	MGIID:	107743	Length:	645	Species:	Mus musculus

Alignment Length:	614	Identity:	132/614 - (21%)
Similarity:	244/614 - (39%)	Gaps:	124/614 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 EEGEGEEDDDGATAKDAAVEDEDVEEEDDE----------------------------------- 178
            ||...:::.|....|:...:|.|::.:..|
Mouse    29 EEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVP 93

  Fly   179 -------EAKGTEGDEGEGEGEGEGAAAR--QEDDEPA-HQAAAVSSKKRKL-------INQFNY 226
                   ::..|..|.|..:....|...|  |.|.:|: .|..:.|...|:|       :.|.::
Mouse    94 TPMSPSSKSVSTPSDAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDF 158

  Fly   227 CERGALTYTNPKRNVDTQTIPPPRSQFGAN------VLQWVIYDSYMENFAESQKDGTKKEERKR 285
            ..|..::|:.     :||| |....|...:      |...:.:||.:||   .:|   |:|.::.
Mouse   159 LPREVVSYSK-----ETQT-PLATHQSEEDEEDEEMVEPKIGHDSELEN---QEK---KQETKEA 211

  Fly   286 GKREKKFRDKSAI--AEQLNKKYLKCWQILERMINQNIYDDIAHDYRYWEDPADEFREGEGNL-- 346
            ..||....:|..|  :|:....:.:..:::||.:.::  .||..||     ...|..|.:|::
Mouse   212 PPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAED--SDIFFDY-----SGRELEEKDGDVQA 269

  Fly   347 ---LPLWKFQYDK--TKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVK-NPSFPD 405
               |...:..||:  :|...||.:.::..|.:|....:.:::......:|...::.:| ..:.|:
Mouse   270 GANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYSNNEDAPHEPDGVALVWNMKFKKTTPE 334

  Fly   406 YIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLY---VSRGVNCKHGECVWQIK 467
            |:......||.......:|.|.|.|.|.|.:.:::.|...:.|:.   :|...:.....||..:
Mouse   335 YVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVV- 398

  Fly   468 WGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVF 532
             |...|.   |..:||:||::.:|.|........::..:|.:         :|....:|   |.|
Mouse   399 -GTQNAH---NLITVSTDGKMCSWSLDMLSTPQESMELVYNK---------SKPVAVTG---MAF 447

  Fly   533 HPVDNKIFLVGTECGYIY-KCSTAFSSKYLMTYYAH---------NMSVYRIDFNRFNSNIFVSC 587
            ...|...|:||:|.|.:| .|.....:.....:..|         :|:|..|||    |::||:.
Mouse   448 PTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDF----SHLFVTS 508

  Fly   588 GADWMVKVWEDMRPDPLFIFDLGA-AVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQ 651
            ..||.||:|......||:.|:..| .|.||.|:|....:||.|...|::.::  |:|....:...
Mouse   509 SFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLW--NLNSDTEVPTA 571

  Fly   652 AVVPKRKNKLTRLSFNEKLAFIVVGDEKG 680
            :|..:..:.|.|:.:.:....:.|||.:|
Mouse   572 SVAIEGASALNRVRWAQGGKEVAVGDSEG 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	82/345 (24%)
		WD40 repeat	362..412	CDD:293791	8/50 (16%)
		WD40	413..640	CDD:295369	62/240 (26%)
		WD40 repeat	415..454	CDD:293791	10/41 (24%)
		WD40 repeat	463..505	CDD:293791	10/41 (24%)
		WD40 repeat	513..557	CDD:293791	12/44 (27%)
		WD40 repeat	571..608	CDD:293791	14/36 (39%)
		WD40 repeat	613..654	CDD:293791	11/40 (28%)
Dync1i1	XP_006505045.1	Dynein_IC2	147..173	CDD:371592	6/31 (19%)
		WD40	283..606	CDD:392136	80/341 (23%)
		WD40 repeat	291..337	CDD:293791	7/45 (16%)
		WD40 repeat	346..385	CDD:293791	8/38 (21%)
		WD40 repeat	393..434	CDD:293791	11/45 (24%)
		WD40 repeat	442..481	CDD:293791	11/41 (27%)
		WD40 repeat	488..529	CDD:293791	15/44 (34%)
		WD40 repeat	535..573	CDD:293791	11/39 (28%)
		WD40 repeat	581..607	CDD:293791	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810