DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9313 and DNAI3

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_660155.2	Gene:	DNAI3 / 126820	HGNCID:	30711	Length:	891	Species:	Homo sapiens

Alignment Length:	854	Identity:	150/854 - (17%)
Similarity:	265/854 - (31%)	Gaps:	280/854 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KSRQLLKP-----DDQLDLTEAELGE-EITKVLTPTNTNIVRN---------------------- 78
            :.::.|||     :|...:....:|. ||..::..|.|..:.|
Human    11 RGKKRLKPVLAASEDMEPVNMESMGHPEIYPLVLTTKTQEIFNCRIDEDVTDEQPYKLINKEDIF 75

  Fly    79 ------LVVYSFKEGEFVPAPLPGNTVTLI-----AFAGNSLHVDSDEGRRQI-------EESDE 125
                  ..|..|...:.:....|||.:.|:     .:..|...:.::||:...       ||.:|
Human    76 EDLRNRAAVSDFHPVKKIVQEYPGNELLLVYDKDFKYGLNFYLIATEEGKENYLNPPEVPEEQEE 140

  Fly   126 IGYPLPMPNYTVVEQRETDNVD-GEEGEGEEDDDGATAKDAAVEDEDVEEEDDE-----EAKGTE 184
            ....:|...|..........|. |.|.|              :|:|.|.|...:     ..|.:|
Human   141 YKEHIPEDVYIYKPPVSKPWVSLGSEKE--------------IEEESVTESTKQITYMISRKRSE 191

  Fly   185 GDEGEGEGEGEGAAARQEDDEPAHQAAAVSSKKRKLINQFNYCERGALTYTNPKRNVDTQTIPPP 249
                      .||..:..|..       .||.|...|....|.::. .|....:::|..|.||..
Human   192 ----------FGAPIKFSDQN-------ASSVKDAYIECTAYPDKN-FTLKQLEKDVGMQVIPQI 238

  Fly   250 RSQFGANVLQWVIYDS-----YMENFAESQKDGTKKEERKRGKREKKFRDKSAIAEQLNKKYLKC 309
            :..  :...:|....:     |...|:|.:     ||..|:.|....|.:.::|:
Human   239 KDI--STQTKWTYPKNATTQYYPREFSEEE-----KETLKQSKPLVDFLNNASIS---------- 286

  Fly   310 WQILERMINQN-IYDDIAHDYRYWEDPADEFREGEGNLLPLWKFQ-----YDKTKKMNVTDILFN 368
               :|..:.|| |.:....|::|..:....|  |:.....|.::|     :..|:|| :|.:.::
Human   287 ---VEIALQQNEIMNTFIDDWKYLAEEEGTF--GDKTDTHLKEYQSFTDLHSPTEKM-ITCVSWH 345

  Fly   369 PSYYDLFAVCFG--------SHDFMKQTNEGYLCLF-TVKNPSFPDYIIQTDCGVMCCDIHPTYP 424
            |:.|.|.||...        .|...|...:..|.|| :..:|..|..::::...:.|....|:.|
Human   346 PTIYGLIAVSVAVRLSFEDRVHFSGKLLLQPSLILFWSFSDPIHPQLMLESPDDIFCFKFCPSDP 410

  Fly   425 FLAVIGLYDGNVAVYNLR-----------------------------EDCKEPLYVSR----GVN 456
            .:...|..:|.:.::::.                             |..||.:|:..    .:.
Human   411 NIIAGGCINGQIVMWDITAHADRIENIKAGGSRSKRATLKPMFLLEPESNKEAMYIRHCAVSSIE 475

  Fly   457 CKHGECVWQIKWGLDMAD----GEV---------NFFSVSSDGRVFNWILMQNKLWVTTIITLYR 508
            ..|.:.:..|.|..|..:    |.|         ...:.|:|..:..|.:...|..........:
Human   476 NGHKKVITDIHWLSDTFEINRMGSVFENRSGICCQLVTCSADCTICFWDIRPQKPLTPQTTEKKK 540

  Fly   509 ENGL---VDGPDG-----------TKVTLKSG--------------------------------- 526
            |..:   .|.|..           |||.|..|
Human   541 EESIEIPFDVPSTFLHLDLSWKPLTKVRLSKGETSLDHCPTKISLNEDHLLCKTQDKMLAQSKTE 605

  Fly   527 -------------GSCMVFHPVDN--KIFLVGTECG-YIY---------KCSTAFSSKYLMTYYA 566
                         |...:..|:|:  ..|.||||.| .||         :.....|.|.:..:..
Human   606 KAEEMNPYHNLESGMANLLKPIDDFCTKFFVGTEEGEVIYTDWKMEKDPETGRLMSKKPVSHHTI 670

  Fly   567 HNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFIFDLGAAVGDV-------------KW 618
            |:.:|:.|..:.|.::|.::.|. |.|.:|::           |...|.:             .|
Human   671 HDGTVHTIQRSPFYNDIILTVGG-WNVAIWKE-----------GVMTGPLLQSCCAPKRYTSGHW 723

  Fly   619 APYSSTVFAAVTTEGKVHVFDLNVNKYKA-----ICIQAVVPKRKNKLTRLSFNEKLAFIVVGDE 678
            :.....||.....:|.:.::||....::.     |||..:     ..:....|:.|..||...|.
Human   724 SLTRPGVFYIGREDGYIDIWDLLEKTHEPAQSQNICITMI-----TYIKPWIFSSKQQFIATADY 783

  Fly   679 KGVTTSLKL 687
            .|....|::
Human   784 YGTLHILEI 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	84/485 (17%)
		WD40 repeat	362..412	CDD:293791	13/58 (22%)
		WD40	413..640	CDD:295369	55/357 (15%)
		WD40 repeat	415..454	CDD:293791	9/71 (13%)
		WD40 repeat	463..505	CDD:293791	9/54 (17%)
		WD40 repeat	513..557	CDD:293791	18/112 (16%)
		WD40 repeat	571..608	CDD:293791	8/36 (22%)
		WD40 repeat	613..654	CDD:293791	10/58 (17%)
DNAI3	NP_660155.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/10 (30%)
		WD40	197..>531	CDD:225201	66/364 (18%)
		WD40	370..793	CDD:225201	73/440 (17%)
		WD 1. /evidence=ECO:0000255	395..435		5/39 (13%)
		WD 2. /evidence=ECO:0000255	477..533		10/55 (18%)
		WD 3. /evidence=ECO:0000255	670..709		11/50 (22%)
		WD 4. /evidence=ECO:0000255	713..753		6/39 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810