DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9313 and dnai1

DIOPT Version :9

Sequence 1:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_031750048.1	Gene:	dnai1 / 100144946	XenbaseID:	XB-GENE-6455855	Length:	703	Species:	Xenopus tropicalis

Alignment Length:	749	Identity:	321/749 - (42%)
Similarity:	430/749 - (57%)	Gaps:	93/749 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KPGKGDGKQVKGKLRTSKNKTDGPGGGGGDADDFDAWMKSRQLLKPDDQLDLTEAELGEEITKVL 68
            ||.|.          .||.|.|......||.  .:.|.:::.|:||.|||:||||||.||.|::|
Frog    22 KPSKA----------ASKKKDDDDSTDVGDG--VEEWTQAKTLIKPRDQLELTEAELNEEFTRIL 74

  Fly    69 TPTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAFAGNSLHVDSDEGRRQ------IEESDEIG 127
            |..|.:..:|:|.|||||..:....:........:..||.||.||||.|||      :|....|.
Frog    75 TANNPHAPQNIVRYSFKERAYKAVSMVEQLAVHFSLDGNLLHKDSDEARRQKLRMGGLEGPTHID 139

  Fly   128 YPLPMPNYTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDVEEEDDEEAKGTEGDEGEGEG 192
            .|...|         .||::.||..|       |...||               |.||.:||
Frog   140 SPAAEP---------ADNMETEEHPG-------TPVPAA---------------GDEGADGE--- 170

  Fly   193 EGEGAAARQEDDEPAHQAAAVSSKKRKLINQFNYCERGALTYTNPKRNVDTQTIPPPRSQFGANV 257
                       |.|       ..|:|||.||||:.||.:.:..||.|....||.||||..|.|:.
Frog   171 -----------DAP-------KLKERKLTNQFNFSERASQSLNNPLRERACQTEPPPREVFSASA 217

  Fly   258 LQWVIYDSYMENFAESQK-------DGTKKEE-----RKRGKREKKFRDKSAIAEQLNKKYLKCW 310
            .||.|||:|:|...:.||       ..:||||     |:.|..|.:..|.|.:|        |..
Frog   218 NQWEIYDAYVEELKKQQKLKEKPKAPASKKEEETPSRRRMGATESQSDDISKLA--------KSC 274

  Fly   311 QILERMINQNIYDDIAHDYRYWEDPADEFREGEGNLLPLWKFQYDKTKKMNVTDILFNPSYYDLF 375
            :|:|||:|||.:||:..|::|:||||||||..||.|:||||||.::.|.:.||.:.:||:|.|||
Frog   275 KIMERMVNQNSFDDVTQDFKYFEDPADEFRGQEGTLMPLWKFQQEQAKGLAVTALCWNPNYKDLF 339

  Fly   376 AVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYN 440
            ||..||:||||| |.|.:..:::||||||:|:...|.||||.|:|..:|:|...|.||||||:||
Frog   340 AVAHGSYDFMKQ-NRGLVLFYSLKNPSFPEYLFSADSGVMCLDLHRDHPYLVAAGFYDGNVAIYN 403

  Fly   441 LREDCKEPLYVSRGVNCKHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIIT 505
            |:.|..:|.::|...:.||.:.|||:||..|..|...|||||||||||.:|.|::::|..:.:|.
Frog   404 LKADTPQPSFISSAKSGKHTDPVWQVKWQRDDMDNNPNFFSVSSDGRVVSWTLVKDELVHSDVIK 468

  Fly   506 LYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNKIFLVGTECGYIYKCSTAFSSKYLMTYYAHNMS 570
            |........||:|.::.:...|:...||.....::|||||.|.|:|||.|:|||:|.||.||:|:
Frog   469 LSFSGTTASGPEGLRLHIHGSGTAFDFHWQTEYLYLVGTEEGNIHKCSKAYSSKFLDTYEAHSMA 533

  Fly   571 VYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFIFDLGAAVGDVKWAPYSSTVFAAVTTEGKV 635
            |..:.:|.|:..:|:||.:||.||:|:.....|:|:|||.|.|.||.|||||||||||||.:|||
Frog   534 VDTVRWNPFHPKVFISCSSDWTVKIWQHDVKSPMFVFDLSAPVADVAWAPYSSTVFAAVTVDGKV 598

  Fly   636 HVFDLNVNKYKAICIQAVVPKRKNKLTRLSFNEKLAFIVVGDEKGVTTSLKLSPNLRMMVKPPKK 700
            |||||:||||:|:|.|.||.|:|.|||.:.||.....::|||::|..||||||||||.|.|..|.
Frog   599 HVFDLSVNKYEALCQQPVVAKKKTKLTHVEFNPVYPILIVGDDRGYVTSLKLSPNLRKMPKEKKG 663

  Fly   701 QLYLDQNTLQIGKLEKLLSLVRE--LPEGSTAVP 732
            |.......:::.||:|||:||||  :.:|.|..|
Frog   664 QEAQKGPEVEVAKLDKLLALVREPDIQQGETESP 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	176/352 (50%)
		WD40 repeat	362..412	CDD:293791	26/49 (53%)
		WD40	413..640	CDD:295369	111/226 (49%)
		WD40 repeat	415..454	CDD:293791	19/38 (50%)
		WD40 repeat	463..505	CDD:293791	21/41 (51%)
		WD40 repeat	513..557	CDD:293791	17/43 (40%)
		WD40 repeat	571..608	CDD:293791	13/36 (36%)
		WD40 repeat	613..654	CDD:293791	31/40 (78%)
dnai1	XP_031750048.1	WD40	<319..665	CDD:225201	174/346 (50%)
		WD40 repeat	326..372	CDD:293791	26/46 (57%)
		WD40 repeat	378..415	CDD:293791	18/36 (50%)
		WD40 repeat	426..483	CDD:293791	26/56 (46%)
		WD40 repeat	491..528	CDD:293791	18/36 (50%)
		WD40 repeat	534..568	CDD:293791	12/33 (36%)
		WD40 repeat	576..617	CDD:293791	31/40 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	384	1.000	Domainoid score	I817
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1054
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007081
OrthoInspector	1	1.000	-	-		oto102435
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4417
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050