DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNA2 and Task7

DIOPT Version :9

Sequence 1:	NP_004965.1	Gene:	KCNA2 / 3737	HGNCID:	6220	Length:	499	Species:	Homo sapiens
Sequence 2:	NP_649891.1	Gene:	Task7 / 41125	FlyBaseID:	FBgn0037690	Length:	340	Species:	Drosophila melanogaster

Alignment Length:	206	Identity:	47/206 - (22%)
Similarity:	80/206 - (38%)	Gaps:	49/206 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   304 IFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWA 368
            |.:.::.:.|.:....|....|...|:|     ..:|:.:.|..|:.. |..|.|    |:|::.
  Fly   140 IIRRAKRASGARCTDATEMNLMLATGML-----SSIIITTGAAVFSRY-EGWSYF----DSFYYC 194

Human   369 VVSMTTVGYGDMVP-------TTIGGKIVGSLCAIA-GVLTIALPVPVIVSNFNYFYHRETEGEE 425
            .|::||:|:||.|.       |...|.:..||..|. |:..:|..:.::|..|......:.:.:|
  Fly   195 FVTLTTIGFGDYVALQNDQALTNKPGYVALSLVFILFGLAVVAASINLLVLRFMTMQAEDAKRDE 259

Human   426 Q-AQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTAN-------- 481
            | ||.|                :.:|..::..|     |...|.:....|.|..|.|
  Fly   260 QDAQNL----------------AGNAQPVTFDD-----ESTYNMHGKLLENNYTTENDETASLCS 303

Human   482 CT-LANTNYVN 491
            || :..|..:|
  Fly   304 CTCMGGTRCLN 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250\|UniProtKB:P63142	1..125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:365784
		Ion_trans	162..420	CDD:395416	30/123 (24%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	312..325		2/12 (17%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	374..379		2/4 (50%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P63142	497..499
Task7	NP_649891.1	Ion_trans_2	<78..133	CDD:285168
Task7	NP_649891.1	Ion_trans_2	166..248	CDD:285168	24/91 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000