Protein Alignment KCNA2 and Shal

DIOPT Version :9

• Sequence 1: NP_004965.1
• Gene: KCNA2 / 3737
• HGNCID: 6220
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Alignment Length: 524
• Identity: 179/524 - (34%)
• Similarity: 283/524 - (54%)
• Gaps: 101/524 - (19%)

Human     2 TVATGDPADEAAAL------------PGHPQD---TYDPEADHECCERVVINISGLRFETQLKTL 51
            :||...|...|||:            |..|:|   |.|        |:::||:||.||||...||
  Fly     3 SVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDD--------EKLLINVSGRRFETWRNTL 59

Human    52 AQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFY 116
            .::|:||||. .:|..::|....||||||:...|..||.||:: |:|..|.:..|..:.||:.|:
  Fly    60 EKYPDTLLGS-NEREFFYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFF 122

Human   117 -----ELGEEAMEMFREDEGYIKEE--ERPLPEN---------EFQRQVWLLFEYPESSGPARII 165
                 .:|:...|.:|:.:....|.  :..|.||         ..::::|..||.|.:|..|.:.
  Fly   123 GIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVF 187

Human   166 AIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDP--------F 222
            ..|:...|.:|:::..:||:|                       .|::...:.|.|        |
  Fly   188 YYVTGFFIAVSVMANVVETVP-----------------------CGHRPGRAGTLPCGERYKIVF 229

Human   223 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQA 287
            |.::|.|::.|:.|:|:|.||.|.:..|..::|:|||:|||:||:|.||  :.:..:
  Fly   230 FCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLG--ITDNDD-------- 284

Human   288 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAD 352
            :|.|.: .:|:.|||||||.||||:||:|||.|||:...|||.|:|.|.:.:|:|::.:::||.:
  Fly   285 VSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKN 348

Human   353 ERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
            ...:.|.|||.|||:.:|:|||:|||||||.||.|||||.:|:::|||.||||||||||||:..|
  Fly   349 VNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIY 413

Human   418 HR-----ETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYME----IQEGVNNSNEDFR 473
            |:     :.:.:.:|:..::...         |.|..|:.:||....|    .||.....::::|
  Fly   414 HQNQRADKRKAQRKARLARIRIA---------KASSGAAFVSKKKAAEARWAAQESGIELDDNYR 469

Human   474 EENL 477
            :|::
  Fly   470 DEDI 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142	1..125		48/142 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		11/38 (29%)
		BTB_POZ	33..159	CDD:365784	47/141 (33%)
		Ion_trans	162..420	CDD:395416	109/270 (40%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	312..325		8/12 (67%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		3/4 (75%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142	497..499
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	48/147 (33%)
		Ion_trans	188..415	CDD:395416	107/260 (41%)
		DUF3399	445..540	CDD:403174	7/29 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810