DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNA2 and CG1688

DIOPT Version :9

Sequence 1:	NP_004965.1	Gene:	KCNA2 / 3737	HGNCID:	6220	Length:	499	Species:	Homo sapiens
Sequence 2:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster

Alignment Length:	169	Identity:	39/169 - (23%)
Similarity:	68/169 - (40%)	Gaps:	25/169 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   338 GVILF----SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAG 398
            |..||    :||:.....|..:||..|..:|..::|..:||:|:|.:.|.|..||:.....|:.|
  Fly   166 GAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVG 230

Human   399 VLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVT---SCPKIPSSPDLKKSRSASTISKSDYME 460
                   ||:::...:      :.|...|..||.|   .|.::....:.::..:..|.:.|
  Fly   231 -------VPLMLMCLS------SLGALLADGLQCTYVRLCCQLQRHQEHRRKSTPGTSTPS---- 278

Human   461 IQEGVNNSNEDF-REENLKTANCTLANTNYVNITKMLTD 498
            .....|:..:|. :....:.|||.....:..|....|.|
  Fly   279 ASSAANSREKDTDKRSKRRMANCKGCQYDAANSETSLND 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250\|UniProtKB:P63142	1..125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:365784
		Ion_trans	162..420	CDD:395416	23/85 (27%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	312..325
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	374..379		2/4 (50%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P63142	497..499		1/2 (50%)
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	16/68 (24%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000