Protein Alignment KCNA2 and CG1688

DIOPT Version :10

• Sequence 1: NP_004965.1
• Gene: KCNA2 / 3737
• HGNCID: 6220
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Alignment Length: 169
• Identity: 39/169 - (23%)
• Similarity: 68/169 - (40%)
• Gaps: 25/169 - (14%)

Human   338 GVILF----SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAG 398
            |..||    :||:.....|..:||..|..:|..::|..:||:|:|.:.|.|..||:.....|:.|
  Fly   166 GAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVG 230

Human   399 VLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVT---SCPKIPSSPDLKKSRSASTISKSDYME 460
                   ||:::...:      :.|...|..||.|   .|.::....:.::..:..|.:.|
  Fly   231 -------VPLMLMCLS------SLGALLADGLQCTYVRLCCQLQRHQEHRRKSTPGTSTPS---- 278

Human   461 IQEGVNNSNEDF-REENLKTANCTLANTNYVNITKMLTD 498
            .....|:..:|. :....:.|||.....:..|....|.|
  Fly   279 ASSAANSREKDTDKRSKRRMANCKGCQYDAANSETSLND 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:453885
		Ion_trans	162..420	CDD:459842	23/85 (27%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	312..325
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		2/4 (50%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142	497..499		1/2 (50%)
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	20/82 (24%)
		Ion_trans_2	822..896	CDD:462301