DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA2 and Shaw

DIOPT Version :10

Sequence 1:NP_004965.1 Gene:KCNA2 / 3737 HGNCID:6220 Length:499 Species:Homo sapiens
Sequence 2:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster


Alignment Length:469 Identity:177/469 - (37%)
Similarity:254/469 - (54%) Gaps:88/469 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    34 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 98
            |||:|:.|:|.||...||.:.|.|.|....:.:..:||:.|||||||:...|..:|.||:: |:|
  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKL 89

Human    99 RRPVNVPLDIFSEEIRFYELG-------------------------------------EEAMEMF 126
            ..|.:|...:|.||:.|:.|.                                     ||....|
  Fly    90 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKF 154

Human   127 REDEGYIK------EEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLET- 184
            ..:|.|.|      :|.:|        ::|.||:.|.||..|:.|.:|||..|.|||:||||:| 
  Fly   155 GFEEDYYKGTISWWQEMKP--------RIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTH 211

Human   185 ----LPIFRDENEDMHGSGVTFHTYSNSTIGY---QQSTSFTDPFFIVETLCIIWFSFEFLVRFF 242
                :||.|:         :|..| :|.:.|:   :..|:....||.:|.:|..||:||.||||.
  Fly   212 PDMRVPIVRN---------ITVKT-ANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFI 266

Human   243 ACPSKAGFFTNIMNIIDIVAIIPYFITLGTE-LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFK 306
            :.|:|..|..:.:||||.:|.:.::|.|..: .|...|:|.         ||....::|:.|:||
  Fly   267 SSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENAD---------ILEFFSIIRIMRLFK 322

Human   307 LSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--ADERESQFPSIPDAFWWAV 369
            |:|||.||:||.||.:||.:||.||:|||.:|:::|:|.||:||  .....:.|.|||...|||:
  Fly   323 LTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWAL 387

Human   370 VSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HRETEG---EEQAQYL 430
            |:|||||||||.|.|..|..||:|||:|||||||||||||||||..:| |.:...   :::.:.|
  Fly   388 VTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVL 452

Human   431 QVTS--CPKIPSSP 442
            .|..  .|::|.:|
  Fly   453 PVEQPRQPRLPGAP 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA2NP_004965.1 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142 1..125 37/127 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
BTB_POZ 33..159 CDD:453885 47/167 (28%)
Ion_trans 162..420 CDD:459842 123/269 (46%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 312..325 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 374..379 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142 497..499
ShawNP_001137782.1 BTB_Shaw-like 24..135 CDD:349723 35/109 (32%)
Ion_trans 188..439 CDD:459842 123/269 (46%)
PRK14959 <418..>585 CDD:184923 21/49 (43%)
Blue background indicates that the domain is not in the aligned region.

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