DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNA2 and CG43155

DIOPT Version :9

Sequence 1:	NP_004965.1	Gene:	KCNA2 / 3737	HGNCID:	6220	Length:	499	Species:	Homo sapiens
Sequence 2:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster

Alignment Length:	181	Identity:	36/181 - (19%)
Similarity:	73/181 - (40%)	Gaps:	38/181 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   312 KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVG 376
            |....:|:|...::..:|      |:||.|.:.|......::..:.|    |.|::..::|||:|
  Fly   230 KFTNFIGKTWFYAILAVG------FLGVYLAAGAGLLLLWEDDWTFF----DGFYFCFITMTTIG 284

Human   377 YGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE------------GEEQAQY 429
            :||:||......::.:|..:.|:...:..:.::...:...:.:..|            ||.....
  Fly   285 FGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQYATSWAKLQELSGPMAETLRRLGETAGTG 349

Human   430 LQVTSCPKI-------------PSSPDLKKSRSASTISKSDYMEIQEGVNN 467
            |..|:..|:             ..|||:   .:...|:.:...|::|..||
  Fly   350 LDYTALQKVLTVSMPKWNSKKNEHSPDI---AALEAITNAILKEVKEAQNN 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250\|UniProtKB:P63142	1..125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:365784
		Ion_trans	162..420	CDD:395416	22/107 (21%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	312..325		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	374..379		2/4 (50%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P63142	497..499
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168
		Ion_trans	<240..314	CDD:278921	19/83 (23%)
		Ion_trans_2	<266..319	CDD:285168	13/56 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000