Protein Alignment KCNA2 and CG43155

DIOPT Version :10

• Sequence 1: NP_004965.1
• Gene: KCNA2 / 3737
• HGNCID: 6220
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 181
• Identity: 36/181 - (19%)
• Similarity: 73/181 - (40%)
• Gaps: 38/181 - (20%)

Human   312 KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVG 376
            |....:|:|...::..:|      |:||.|.:.|......::..:.|    |.|::..::|||:|
  Fly   230 KFTNFIGKTWFYAILAVG------FLGVYLAAGAGLLLLWEDDWTFF----DGFYFCFITMTTIG 284

Human   377 YGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE------------GEEQAQY 429
            :||:||......::.:|..:.|:...:..:.::...:...:.:..|            ||.....
  Fly   285 FGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQYATSWAKLQELSGPMAETLRRLGETAGTG 349

Human   430 LQVTSCPKI-------------PSSPDLKKSRSASTISKSDYMEIQEGVNN 467
            |..|:..|:             ..|||:   .:...|:.:...|::|..||
  Fly   350 LDYTALQKVLTVSMPKWNSKKNEHSPDI---AALEAITNAILKEVKEAQNN 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:453885
		Ion_trans	162..420	CDD:459842	22/107 (21%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	312..325		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		2/4 (50%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142	497..499
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301
		Ion_trans_2	<267..319	CDD:462301	13/55 (24%)