DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA2 and SK

DIOPT Version :9

Sequence 1:NP_004965.1 Gene:KCNA2 / 3737 HGNCID:6220 Length:499 Species:Homo sapiens
Sequence 2:NP_001284887.1 Gene:SK / 31456 FlyBaseID:FBgn0029761 Length:1174 Species:Drosophila melanogaster


Alignment Length:311 Identity:73/311 - (23%)
Similarity:121/311 - (38%) Gaps:95/311 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   152 LFEYPES-SGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGV----TFHTYSNSTIG 211
            |||..:. |..|.::.:..::|::|               ||| :..:||    :|::.:..|: 
  Fly   475 LFEKRKRISDYALVMGMFGIIVMVI---------------ENE-LSSAGVYTKASFYSTALKTL- 522

Human   212 YQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAG------FFTNIMNI---IDIVAIIP-- 265
            ...||      .|:..|.:.:.:.|..||.|...:.|.      .:..|..|   :.|.||.|  
  Fly   523 ISVST------VILLGLIVAYHALEVQVRLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIP 581

Human   266 --YFITLGTELAEK---------PEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQ 319
              |:....|:||.|         |.|.     |:||.:.  :||..:.|:..|  |||      .
  Fly   582 GEYYFQWTTKLANKNKTIGTEMVPYDV-----ALSLPMF--LRLYLICRVMLL--HSK------L 631

Human   320 TLKASMRELG------------------------LLIFFLFIGVILFSSAVYFAEADER--ESQF 358
            ...||.|.:|                        ||:|.:.:.:|    |.:.....||  :.:.
  Fly   632 FTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWII----ASWTLRQCERFHDEEH 692

Human   359 PSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVI 409
            .::.:|.|...::..:||:||:||.|..|:.:.....|.|....||.|.|:
  Fly   693 ANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVV 743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA2NP_004965.1 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142 1..125
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
BTB_POZ 33..159 CDD:365784 3/7 (43%)
Ion_trans 162..420 CDD:395416 69/300 (23%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 312..325 2/12 (17%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 374..379 2/4 (50%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142 497..499
SKNP_001284887.1 SK_channel 472..582 CDD:281522 29/129 (22%)
Ion_trans_2 669..748 CDD:285168 21/79 (27%)
CaMBD 762..834 CDD:280961
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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