DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act57B and Actl6b

DIOPT Version :9

Sequence 1:	NP_523800.1	Gene:	Act57B / 37368	FlyBaseID:	FBgn0000044	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_006504698.1	Gene:	Actl6b / 83766	MGIID:	1933548	Length:	434	Species:	Mus musculus

Alignment Length:	436	Identity:	159/436 - (36%)
Similarity:	232/436 - (53%)	Gaps:	75/436 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVG--RPRHQGVMVGMGQKDS------------Y 54
            |||.|||.|.||...:||:||:|.|:|.||:.||  .....|.:...|:|:.            :
Mouse     9 DEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGEKEKKGKIFHIDTNALH 73

  Fly    55 V---GDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKAN 116
            |   |.|..|         |:::|:|.:|:....|..||:...::..|..||||::|||.|.:|.
Mouse    74 VPRDGAEVMS---------PLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAK 129

  Fly   117 REKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT--VPIYEGYALPHAILRL 179
            |||:|::|||.:|.||.::...|||:.:|:||:||:||||  |.:||  :|:::||.|...|::.
Mouse   130 REKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDS--GATHTTAIPVHDGYVLQQGIVKS 192

  Fly   180 DLAGRDLTDYLMKILTERGYSFT---TTAEREIVRD-------IKEKLCYVA------------L 222
            .|||..::....::..|......   ..|.:|.||:       .||||..|:            .
Mouse   193 PLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQ 257

  Fly   223 DFEQEMATAAASTSLEK--------SYELPDGQVITIGNERFRCPESLFQPS----FLGMESCGI 275
            ||:..:...:.|...|:        .||:|:|.....|.||.|.||.||.||    ..|....|:
Mouse   258 DFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGV 322

  Fly   276 HETVYNSIMKCDVDIR--------KDLYANIVMSGGTTMYPGIADRMQKEITSLAPSTIKIKIIA 332
            ...|..||..||:|||        :.||.:::::||.|:..|..||:.:|::...|.::::|:||
Mouse   323 GHVVTTSIGMCDIDIRPVDASPCSQGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIA 387

  Fly   333 ---PPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHRKC 375
               ..|||:|.||||||||||.|||||||||:||:|.|...|.|||
Mouse   388 SNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act57B	NP_523800.1	PTZ00281	1..376	CDD:173506	159/436 (36%)
Actl6b	XP_006504698.1	Actin	11..434	CDD:306521	157/434 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820