DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act57B and Actl11

DIOPT Version :9

Sequence 1:	NP_523800.1	Gene:	Act57B / 37368	FlyBaseID:	FBgn0000044	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001019959.2	Gene:	Actl11 / 316000	RGDID:	1310036	Length:	1218	Species:	Rattus norvegicus

Alignment Length:	369	Identity:	148/369 - (40%)
Similarity:	223/369 - (60%)	Gaps:	21/369 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLK 69
            ::||:|:|.|:|..|.|.|.::...:|.||.|...:|.    ..||....|.:..:....:|
  Rat   868 KMAAIVIDTGTGFTKCGLAQENHVLSVVPSQVQMLQHP----PQGQPQYVVPEHQEGSYSVL--- 925

  Fly    70 YPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMY 134
               ..|::::||.:|.:|.|.||.:|||.|||..||:.::|::|:.||||:.:|:||.|:.|||.
  Rat   926 ---NRGVVSDWDALEVLWQHLFYCKLRVQPEEMAVLVADSPISPRTNREKVAEILFERFHVPAMQ 987

  Fly   135 VAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGY 199
            ...||:|:|||.|||||:|:.||.|.|:..||..|...|....|||:||.||||||.::|...|:
  Rat   988 TVHQALLTLYAYGRTTGLVVGSGHGTSYVAPIITGDLAPLDTYRLDVAGADLTDYLAQLLMSGGH 1052

  Fly   200 SFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPESLFQ 264
            |   ..:..|||.|||..||||:|...|||...:...::  :.|||..|||:|:|||.|||:|||
  Rat  1053 S---PPKGGIVRQIKEACCYVAMDTTTEMARNQSQVQVD--FVLPDKHVITLGSERFCCPEALFQ 1112

  Fly   265 PSFLGMESCGIHETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITSLAPSTIKIK 329
            |:.||:...|:.:....||.:.:|..::.|.||:|:.||:|:..|..:||::|   |.|..   .
  Rat  1113 PNLLGLNQLGLPQLALLSISRLEVKQQEQLLANVVLEGGSTLINGFPERMRQE---LGPGA---T 1171

  Fly   330 IIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHR 373
            ::..|.|..:.|:||||:|...:||.:|:|:.||:|.||..:::
  Rat  1172 VLGSPHRAVAAWLGGSIMACRDSFQSLWLSRREYEEEGPWAIYK 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act57B	NP_523800.1	PTZ00281	1..376	CDD:173506	148/369 (40%)
Actl11	NP_001019959.2	PHA03247	<200..485	CDD:223021
Actl11	NP_001019959.2	NBD_sugar-kinase_HSP70_actin	871..1215	CDD:418402	147/364 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000