DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act57B and ACTL7A

DIOPT Version :9

Sequence 1:	NP_523800.1	Gene:	Act57B / 37368	FlyBaseID:	FBgn0000044	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_006678.1	Gene:	ACTL7A / 10881	HGNCID:	161	Length:	435	Species:	Homo sapiens

Alignment Length:	370	Identity:	163/370 - (44%)
Similarity:	240/370 - (64%)	Gaps:	6/370 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPI 72
            |:|||.|:|.||.||||...|.....:.||:|..:....|..:|:::||.|..:....|.|..|:
Human    71 AVVVDLGTGYCKCGFAGLPRPTHKISTTVGKPYMETAKTGDNRKETFVGQELNNTNVHLKLVNPL 135

  Fly    73 EHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAI 137
            .||||.:||.::.||.:.|..|:::|||||.||:::.||:|..||||..:::||.||:|||::|.
Human   136 RHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFEAFNTPAMHIAY 200

  Fly   138 QAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFT 202
            |:.||:|:.|||:|:|::.|.|||:.|||||||.||....|||.||.|||.||:.:|...|..||
Human   201 QSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTAYLLGLLNSAGNEFT 265

  Fly   203 TTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPESLFQPSF 267
            .. :..||.|||:|.|:||||..:|.....:..::.  |.||||:.|.:..|||.|.|..|:||.
Human   266 QD-QMGIVEDIKKKCCFVALDPIEEKKVPLSEHTIR--YVLPDGKEIQLCQERFLCSEMFFKPSL 327

  Fly   268 LGMESCGIHETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITSLAPS-TIKIKII 331
            :.....|:|....:.:.|||:.:::||..||::.||:||..|..:|:|||::|:.|: |.::.::
Human   328 IKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTPQVNVL 392

  Fly   332 APPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHRKCF 376
              |||..:||.||||||||..||.:|:.:.||:|.||..::|:||
Human   393 --PERDSAVWTGGSILASLQGFQPLWVHRFEYEEHGPFFLYRRCF 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act57B	NP_523800.1	PTZ00281	1..376	CDD:173506	161/368 (44%)
ACTL7A	NP_006678.1	ACTL7A_N	1..65	CDD:293445
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		Required for interaction with TES	31..51
		NBD_sugar-kinase_HSP70_actin	67..435	CDD:302596	161/368 (44%)
		ACTIN	69..435	CDD:214592	161/368 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910