DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Act57B and ACTL7A

DIOPT Version :10

Sequence 1:NP_523800.1 Gene:Act57B / 37368 FlyBaseID:FBgn0000044 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_006678.1 Gene:ACTL7A / 10881 HGNCID:161 Length:435 Species:Homo sapiens


Alignment Length:370 Identity:163/370 - (44%)
Similarity:240/370 - (64%) Gaps:6/370 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPI 72
            |:|||.|:|.||.||||...|.....:.||:|..:....|..:|:::||.|..:....|.|..|:
Human    71 AVVVDLGTGYCKCGFAGLPRPTHKISTTVGKPYMETAKTGDNRKETFVGQELNNTNVHLKLVNPL 135

  Fly    73 EHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAI 137
            .||||.:||.::.||.:.|..|:::|||||.||:::.||:|..||||..:::||.||:|||::|.
Human   136 RHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFEAFNTPAMHIAY 200

  Fly   138 QAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFT 202
            |:.||:|:.|||:|:|::.|.|||:.|||||||.||....|||.||.|||.||:.:|...|..||
Human   201 QSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTAYLLGLLNSAGNEFT 265

  Fly   203 TTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPESLFQPSF 267
            .. :..||.|||:|.|:||||..:|.....:..::.  |.||||:.|.:..|||.|.|..|:||.
Human   266 QD-QMGIVEDIKKKCCFVALDPIEEKKVPLSEHTIR--YVLPDGKEIQLCQERFLCSEMFFKPSL 327

  Fly   268 LGMESCGIHETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITSLAPS-TIKIKII 331
            :.....|:|....:.:.|||:.:::||..||::.||:||..|..:|:|||::|:.|: |.::.::
Human   328 IKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTPQVNVL 392

  Fly   332 APPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHRKCF 376
              |||..:||.||||||||..||.:|:.:.||:|.||..::|:||
Human   393 --PERDSAVWTGGSILASLQGFQPLWVHRFEYEEHGPFFLYRRCF 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Act57BNP_523800.1 ASKHA_NBD_actin 7..371 CDD:466823 160/363 (44%)
ACTL7ANP_006678.1 ACTL7A_N 1..65 CDD:465280
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..64
Required for interaction with TES 31..51
ASKHA_NBD_ACTL7 67..434 CDD:466819 161/367 (44%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.