DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rx and ESX1

DIOPT Version :9

Sequence 1:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_703149.1	Gene:	ESX1 / 80712	HGNCID:	14865	Length:	406	Species:	Homo sapiens

Alignment Length:	431	Identity:	118/431 - (27%)
Similarity:	167/431 - (38%)	Gaps:	125/431 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 SQINYDERSMSSASDLEEDDDDAAKLQLDVTSPPTPSPRGQLAAKRKSAGVFCDDNEPKLANGQL 443
            |.|.|  ||::...|:||.:|:    :|.|||         |.|:   .|...::...|...|..
Human    10 SDIGY--RSLAVGEDIEEVNDE----KLTVTS---------LMAR---GGEDEENTRSKPEYGTE 56

  Fly   444 PGGNYGIRPRSMEEVHHQQQSHHHQQQQQQ---------QQQQQ----QLQQQQGFQHDFRNSGN 495
            ...|.|.......:...::....|:.:|||         |||::    :|:|:|
Human    57 AENNVGTEGSVPSDDQDREGGGGHEPEQQQEEPPLTKPEQQQEEPPLLELKQEQ----------- 110

  Fly   496 GNPNGNSNSGDHGERLNADSDSLVNGSCASSEDLNQTNSSEQGEKITSGSDD-EGQDDNCAKKKH 559
                                           |:..||  :.:|.:...|... ||..   ..::.
Human   111 -------------------------------EEPPQT--TVEGPQPAEGPQTAEGPQ---PPERK 139

  Fly   560 RRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLR 624
            ||.||.||.:||.|||..|::|.||||.:||.||.::||.|.|||||||||||||:|.::...||
Human   140 RRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQRVLMLR 204

  Fly   625 LGLTHFTQLPHRLGCGASG-------------------LPVDPWLSPPLLSALPGFLSHPQTVYP 670
            ...|  ..|.|.|.....|                   ||..|.|..|.:...|..:..|... |
Human   205 NTAT--ADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLPVPPMPPRPPMVPMPPRP-P 266

  Fly   671 SYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPHGVPHPHGSHHVV 735
            ....||::..|....|:.:           ||.|.:.......|..|.||.|...|.|.|.
Human   267 IAPMPPMAPVPPGSRMAPV-----------PPGPRMAPVPPWPPMAPVPPWPPMAPVPTGP---- 316

  Fly   736 PLSHL--SPHLSRMSPHATSLGSPHHGVTPLGTPLHSSLPP 774
            |::.:  .|.::|:.|     |.|...|.| |.|: :.|||
Human   317 PMAPVPPGPPMARVPP-----GPPMARVPP-GPPM-APLPP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	34/51 (67%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		5/12 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..142		28/167 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		2/4 (50%)
		Homeobox	142..195	CDD:278475	34/52 (65%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378		34/130 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..364		6/12 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910