DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rx and ALX4

DIOPT Version :9

Sequence 1:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_068745.2	Gene:	ALX4 / 60529	HGNCID:	450	Length:	411	Species:	Homo sapiens

Alignment Length:	529	Identity:	143/529 - (27%)
Similarity:	192/529 - (36%)	Gaps:	201/529 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 TSPPTPSPRGQ------LAAKRKSAGVFCDDNEPKLANGQ------LPGGNYGIRPRSMEEVHHQ 461
            :||....|.|.      |:|..|:.|.....:..:...||      |..| .|.| .|..:...|
Human    31 SSPFRAFPGGDKFGTTFLSAAAKAQGFGDAKSRARYGAGQQDLATPLESG-AGAR-GSFNKFQPQ 93

  Fly   462 QQSHHHQQQQQQQQQQQQLQQQQGFQ-HDF--RNSGNGNPNGN----SNSGDH------------ 507
            ..:...|...|.|.||||.|.|...| |.:  |.:....|:|:    ..|..|
Human    94 PSTPQPQPPPQPQPQQQQPQPQPPAQPHLYLQRGACKTPPDGSLKLQEGSSGHSAALQVPCYAKE 158

  Fly   508 ---GE-RLNADSDSLVNGSCASSEDLNQTNSSEQGEKITSGSDD----------EGQDDNCAKKK 558
               || .|..|||::       ..|.:..:..|.|.|   |..|          |..|....|.|
Human   159 SSLGEPELPPDSDTV-------GMDSSYLSVKEAGVK---GPQDRASSDLPSPLEKADSESNKGK 213

  Fly   559 HRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESL 623
            .||||||||:|||.|||:.|:|:||||||:||:|||:.:|.|.||||||||||||||::|:...:
Human   214 KRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQM 278

  Fly   624 RLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGFLSHPQTVYPSYLTPPLSLAPGNLTMSS 688
            :...|||: ..:.|               |||:...   ::.|...||:|
Human   279 QQVRTHFS-TAYEL---------------PLLTRAE---NYAQIQNPSWL--------------- 309

  Fly   689 LAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHATS 753
                              |:.|...|.|....|...||                  :.|||||
Human   310 ------------------GNNGAASPVPACVVPCDPVP------------------ACMSPHA-- 336

  Fly   754 LGSPHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNG 818
                           |   ||.|.|::|.                        ..||:..|.|:.
Human   337 ---------------H---PPGSGASSVT------------------------DFLSVSGAGSHV 359

  Fly   819 DGRDLSSDLDAGSTSSNPGSSLDKCAASANIELLDVGRDSPPPPPTPTGKGSSTPPTDMRSNSIA 883
            ....:.|..  |:.|.:||.:               |.:....|             |.:::|||
Human   360 GQTHMGSLF--GAASLSPGLN---------------GYELNGEP-------------DRKTSSIA 394

  Fly   884 TLRIKAKEH 892
            .||:|||||
Human   395 ALRMKAKEH 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	38/51 (75%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	9/15 (60%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..145		21/71 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		12/37 (32%)
		Homeobox	218..270	CDD:278475	38/51 (75%)
		OAR	387..404	CDD:281777	11/17 (65%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	391..404		10/13 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920