DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rx and phox2bb

DIOPT Version :9

Sequence 1:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001014818.1	Gene:	phox2bb / 544654	ZFINID:	ZDB-GENE-050407-3	Length:	284	Species:	Danio rerio

Alignment Length:	320	Identity:	89/320 - (27%)
Similarity:	125/320 - (39%)	Gaps:	91/320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 QQQGFQHDFRNSGNGNPNGNSNSGDHGERLNADSDSLVNGSCASSEDLNQTNSSEQGEKITSGSD 546
            |..|||:        ||...:.....|      ..||..|||:.....:..:|..........:|
Zfish    38 QASGFQY--------NPIRTTFGATSG------CPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTD 88

  Fly   547 DEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRR 611
            ..|.::   |:|.||.|||||:.||.||||.|.::||||:|:|||||:|::|.|.||||||||||
Zfish    89 HGGLNE---KRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRR 150

  Fly   612 AKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGFLSHPQTVYPSYLTPP 676
            ||:|:||::.:.......          ..:|...|               |..:....:..|.|
Zfish   151 AKFRKQERAAAAAAAAAK----------NGTGKKSD---------------SREEDSKEAKATDP 190

  Fly   677 LSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPH-GVPHPHGSHHVV----P 736
            .|.                                |.|.|.|.|..: |.|.|.|.....    |
Zfish   191 DST--------------------------------GGPGPNPNPTSNCGGPSPTGGQVSATGNGP 223

  Fly   737 LSHLSPHLSRMSPHATSLG---SPHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSSSSA 793
            :..:...::.|.|.|.:.|   :|       ||  .:|:|.|......:|.||....:.|
Zfish   224 VEQVKTSVAGMGPTAPTQGWASAP-------GT--ITSIPDSLGGPFASVLSSLQRQNGA 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	37/51 (73%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
phox2bb	NP_001014818.1	Homeobox	102..154	CDD:278475	37/51 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910