DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rx and PITX3

DIOPT Version :9

Sequence 1:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_005020.1	Gene:	PITX3 / 5309	HGNCID:	9006	Length:	302	Species:	Homo sapiens

Alignment Length:	380	Identity:	99/380 - (26%)
Similarity:	142/380 - (37%)	Gaps:	148/380 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 CASSEDLNQTNSSEQGEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVY 587
            |...|   .::|.:....:..||.::|.    .|||.||.||.||:.||.|||..|:::.|||:.
Human    33 CKGQE---HSDSEKASASLPGGSPEDGS----LKKKQRRQRTHFTSQQLQELEATFQRNRYPDMS 90

  Fly   588 SREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWLSP 652
            :|||:|:..||.|.||:|||:|||||||::|:|:...|             |..|       .:.
Human    91 TREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAEL-------------CKGS-------FAA 135

  Fly   653 PLLSALPGFLSHPQTVYPSYL---TPPLSLAPGNLTMSSLAAMGHHHAHN----GPPPPHVGHGG 710
            ||...:|.:    :.|||.|.   .||.:|||      .|||.....|.|    ||..
Human   136 PLGGLVPPY----EEVYPGYSYGNWPPKALAP------PLAAKTFPFAFNSVNVGPLA------- 183

  Fly   711 HGQP--QPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHA-TSLGSPHHGVTPLGTPLHSSL 772
             .||  .||.......||....:...||           .|.| ..||....|:.|
Human   184 -SQPVFSPPSSIAASMVPSAAAAPGTVP-----------GPGALQGLGGGPPGLAP--------- 227

  Fly   773 PPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSSNPG 837
               :..::.|||...:|:::|                                   |.:.:|:|.
Human   228 ---AAVSSGAVSCPYASAAAA-----------------------------------AAAAASSPY 254

  Fly   838 SSLDKCAASANIELLDVGRDSPPPPPTPTGKGSSTPPTDMRSNSIATLRIKAKEH 892
            ...|.|                                   ::|:|:||:|||:|
Human   255 VYRDPC-----------------------------------NSSLASLRLKAKQH 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	30/51 (59%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	7/15 (47%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		14/44 (32%)
		Homeobox	66..119	CDD:395001	31/52 (60%)
		OAR	258..275	CDD:397759	10/52 (19%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	262..275		8/13 (62%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910