Protein Alignment Rx and PITX2

DIOPT Version :10

• Sequence 1: NP_726006.3
• Gene: Rx / 37367
• FlyBaseID: FBgn0020617
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 114/493 - (23%)
• Similarity: 174/493 - (35%)
• Gaps: 216/493 - (43%)

  Fly   417 RGQLAAKRKSAGV--------FCDDNEP-KLANGQLPGGNYGIRPRSMEEVHHQQQSHHHQQQQQ 472
            :|.|..:.::||.        .|...:| .:|:...||     :|||::...|:.:.|
Human     5 KGPLHLEHRAAGTKLSAVSSSSCHHPQPLAMASVLAPG-----QPRSLDSSKHRLEVH------- 57

  Fly   473 QQQQQQQLQQQQGFQHDFRNSGNGNPNGNSNSGDHGERLNADSDSLVNGSCASSEDLNQTNSSEQ 537
                                                    ..||:       ||.:..:.:.|:|
Human    58 ----------------------------------------TISDT-------SSPEAAEKDKSQQ 75

  Fly   538 GEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVR 602
            |:     ::|.|.:|...||:.||.||.||:.||.|||..|:::.|||:.:|||:|:..||.|.|
Human    76 GK-----NEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEAR 135

  Fly   603 VQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGFLSHPQT 667
            |:|||:|||||||::|:::...|....|       |...:|| :.|:                ..
Human   136 VRVWFKNRRAKWRKRERNQQAELCKNGF-------GPQFNGL-MQPY----------------DD 176

  Fly   668 VYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPHGVPHPHGSH 732
            :||.|...  :.|...||.:||:
Human   177 MYPGYSYN--NWAAKGLTSASLS------------------------------------------ 197

  Fly   733 HVVPLSHLSPHLSRMSPHATSLGSPHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSSSSASLEC 797
                        ::..|...|:     .|.||.:....| ||:|.       ||.|.|||
Human   198 ------------TKSFPFFNSM-----NVNPLSSQSMFS-PPNSI-------SSMSMSSS----- 232

  Fly   798 SGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSSNPGSSLDKCAASANIELLDVGRDSPPP- 861
                  |.|                       .:.:..|||||:......|:....:....|.|
Human   233 ------MVP-----------------------SAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPA 268

  Fly   862 ----PPTPTGKGSSTPP---TDMRSNSIATLRIKAKEH 892
                ||        |||   .|..::|:|:||:|||:|
Human   269 CPYAPP--------TPPYVYRDTCNSSLASLRLKAKQH 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeodomain	560..616	CDD:459649	33/55 (60%)
		OAR	876..892	CDD:461067	8/15 (53%)
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	33/55 (60%)
		OAR	282..299	CDD:461067	9/17 (53%)