DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rx and PITX1

DIOPT Version :9

Sequence 1:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_002644.4	Gene:	PITX1 / 5307	HGNCID:	9004	Length:	314	Species:	Homo sapiens

Alignment Length:	362	Identity:	100/362 - (27%)
Similarity:	141/362 - (38%)	Gaps:	119/362 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 ADSDSLVNGSCASSEDLNQTNSSEQGEKITSGSDDE--------GQDDNCAKKKHRRNRTTFTTY 569
            ||....:..|.:.|.|.........||  ..|.:|.        |.||...|||.||.||.||:.
Human    37 ADPREPLENSASESSDTELPEKERGGE--PKGPEDSGAGGTGCGGADDPAKKKKQRRQRTHFTSQ 99

  Fly   570 QLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRL----GLTHF 630
            ||.|||..|:::.|||:..|||:|:..||.|.||:|||:|||||||::|:::.|.|    .:..|
Human   100 QLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQF 164

  Fly   631 TQL--PHRLGCGASGLPVDPW----LSPPLLS-------------ALPGFLSHPQTVYPSYLTPP 676
            :.|  |:. ...|:|...:.|    |:|..||             :.....|.|.::  |.:|.|
Human   165 SGLVQPYE-DVYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSI--SSMTMP 226

  Fly   677 LSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPHGVPHPHGSHHVVPLSHLS 741
            .|:.||.:.                                      |:|: .|.:::..|:..|
Human   227 SSMGPGAVP--------------------------------------GMPN-SGLNNINNLTGSS 252

  Fly   742 PHLSRMSPHATSLGSPHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSSSSASLECSGPDVCMSP 806
            .: |.|||          |..|.|||          |:..:|.....:||.|||...      |.
Human   253 LN-SAMSP----------GACPYGTP----------ASPYSVYRDTCNSSLASLRLK------SK 290

  Fly   807 QNLSIGNADSNGDGRDLSSDLDAGSTSSNPGSSLDKC 843
            |:.|.|.....|                 |.|.|:.|
Human   291 QHSSFGYGGLQG-----------------PASGLNAC 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	30/51 (59%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
PITX1	NP_002644.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		23/67 (34%)
		COG5576	36..>146	CDD:227863	48/110 (44%)
		Homeobox	93..146	CDD:395001	31/52 (60%)
		Interaction with PIT-1. /evidence=ECO:0000250	147..279		37/194 (19%)
		OAR	276..293	CDD:397759	7/22 (32%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	280..293		7/18 (39%)
		Nuclear localization signal. /evidence=ECO:0000255	286..290		0/9 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910