DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rx and pitx3

DIOPT Version :9

Sequence 1:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_991238.1	Gene:	pitx3 / 402974	ZFINID:	ZDB-GENE-041229-4	Length:	293	Species:	Danio rerio

Alignment Length:	386	Identity:	101/386 - (26%)
Similarity:	154/386 - (39%)	Gaps:	143/386 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 ADSDSLVNGSCASSEDLNQTNSSEQGEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERA 577
            :||.:..:......:|.:.|..|.|..     :|:...:|...|||.||.||.||:.||.|||..
Zfish    19 SDSGTPQHDPGCKGQDNSDTEKSHQNH-----TDESNPEDGSLKKKQRRQRTHFTSQQLQELEAT 78

  Fly   578 FEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGAS 642
            |:::.|||:.:|||:|:..||.|.||:|||:|||||||::|:::...|....|       |...:
Zfish    79 FQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGF-------GAQFN 136

  Fly   643 GL--PVDPWLSPPLLSALPGFLSHPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPH 705
            ||  |.|...|        |:         ||         .|....|||:
Zfish   137 GLMQPYDDMYS--------GY---------SY---------NNWATKSLAS-------------- 161

  Fly   706 VGHGGHGQPQPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHATSLGSPHHGVTPLGT-PLH 769
                                               ||..::..|...|:     .|:||.: |:.
Zfish   162 -----------------------------------SPLSAKSFPFFNSM-----NVSPLSSQPMF 186

  Fly   770 SSLPPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSS 834
            |  |||| ..::.::||...|:.|.:..||.:        ::||.:      :|:|
Zfish   187 S--PPSS-IPSMNMASSMVPSAVAGVPGSGLN--------NLGNLN------NLNS--------- 225

  Fly   835 NPGSSLDKCAASANIELLDVGRDSPPPPPTPTGKGSSTPP---TDMRSNSIATLRIKAKEH 892
               .:|:..|.||          :..|..|..|      |   .|..::|:|:||:|||:|
Zfish   226 ---PTLNSAAVSA----------AACPYATTAG------PYMYRDTCNSSLASLRLKAKQH 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	30/51 (59%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	8/15 (53%)
pitx3	NP_991238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		16/54 (30%)
		Cnd2	18..>79	CDD:303063	22/64 (34%)
		Homeobox	64..116	CDD:278475	30/51 (59%)
		OAR	251..268	CDD:281777	9/17 (53%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	255..268		8/13 (62%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O35160	260..264		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910