Protein Alignment Rx and Arx

DIOPT Version :9

• Sequence 1: NP_726006.3
• Gene: Rx / 37367
• FlyBaseID: FBgn0020617
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_001093644.1
• Gene: Arx / 317268
• RGDID: 1562672
• Length: 566
• Species: Rattus norvegicus
• Alignment Length: 790
• Identity: 177/790 - (22%)
• Similarity: 254/790 - (32%)
• Gaps: 313/790 - (39%)

  Fly   167 RNPETVSDGSVDPSLGDDDATDLRCGMTLTQLRSMDNHMASMLQQHAKNGGALPYGPPTPPGGQQ 231
            ::|..:|...:|..||......:|   .|...:|:...:||...|.....|       :|.|...
  Rat    19 KSPTLLSSYCIDSILGRRSPCKMR---LLGAAQSLPAPLASRTDQEKAMQG-------SPKGSSA 73

  Fly   232 PQVPNATPLHHGQQMGGQAGHATHAGHGHPTHHGHAPFGYHNAFGFGQGGHGYGHPEEAAGNYLN 296
            |.....                            |.|......:|.|.|....|....||.
  Rat    74 PFEAEL----------------------------HLPPKLRRLYGPGGGRLLQGAAAAAAA---- 106

  Fly   297 SMHQMVEANQLQTGANGANP----PPAPLPPSSFGSHQQHLAALAAQA----------QEQQNQH 347
               ....|....|....|.|    ||.|.|.:..|..|....|:||.|          |..|...
  Rat   107 ---AAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAWDTLKISQAPQVSI 168

  Fly   348 SKYAKSSPTGAGP--PPPPGAYFMESQTAPVAPSQINYDERSMSSASDLEEDDDDAAKLQLDVTS 410
            |: :||......|  ||||....:.      .|..:.:.|..:|:||
  Rat   169 SR-SKSYRENGAPFVPPPPALDELG------GPGGVAHPEERLSAAS------------------ 208

  Fly   411 PPTPSPRGQLAAKRKSAGVFCDDNEPKLANGQLPGGNYGIRPRSMEEVHHQQQSHHHQQQQQQQQ 475
                   |..:|.....|...:::|                    ||:...::....:::..:..
  Rat   209 -------GPGSAPAAGGGTGTEEDE--------------------EELLEDEEDEDEEEELLEDD 246

  Fly   476 QQQQLQQ------QQGFQHDFRNSGN-----GNPNGNSNSGDHGERLNADSDSLVNGSCASSEDL 529
            :::.|:.      ::..:.....:|.     ......:.....|..|:...:.|::...|..:|
  Rat   247 EEELLEDDARALLKEPRRCSVATTGTVAAAAAAAAAAAAVATEGGELSPKEELLLHPEDAEGKD- 310

  Fly   530 NQTNSSEQGEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAM 594
                 .|....:::|||.|   :...|:|.||.|||||:|||.||||||:|:|||||::||||||
  Rat   311 -----GEDSVCLSAGSDSE---EGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAM 367

  Fly   595 KVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALP 659
            :::|.|.||||||||||||||::||:.:    .||           ..|||            .|
  Rat   368 RLDLTEARVQVWFQNRRAKWRKREKAGA----QTH-----------PPGLP------------FP 405

  Fly   660 GFLS--HPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPP-- 720
            |.||  ||       |:|.|..:|         ...||.|.:..............|..||||
  Rat   406 GPLSATHP-------LSPYLDASP---------FPPHHPALDSAWTAAAAAAAAAFPSLPPPPGS 454

  Fly   721 ---PPHGVP-------------HPHGSHHVVPLSHLSPHLSRMSPHATSLGSPHHGVTPLGTPLH 769
               ||.|.|             ||         :.:||...|                     |.
  Rat   455 ASLPPSGAPLGLSTFLGAAVFRHP---------AFISPAFGR---------------------LF 489

  Fly   770 SSLPPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSS 834
            |::.|.::|:|.|....|
  Rat   490 STMAPLTSASTAAALLRQ----------------------------------------------- 507

  Fly   835 NPGSSLDKCAASANIELLDVGRDSPPPPPTPTGKGS---------STPPTDMRSNSIATLRIKAK 890
                                        |||..:|:         :|...|.|::|||.||:|||
  Rat   508 ----------------------------PTPAVEGAVASGALADPATAAADRRASSIAALRLKAK 544

  Fly   891 EH---LDNLN 897
            ||   |..||
  Rat   545 EHAAQLTQLN 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	40/51 (78%)
		OAR	876..892	CDD:281777	10/15 (67%)
Arx	NP_001093644.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..79		7/35 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..264		34/196 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..319		6/38 (16%)
		Homeobox	336..388	CDD:278475	40/51 (78%)
		OAR	530..547	CDD:281777	11/16 (69%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	534..547		9/12 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920