Protein Alignment Rx and pitx2

DIOPT Version :10

• Sequence 1: NP_726006.3
• Gene: Rx / 37367
• FlyBaseID: FBgn0020617
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_571050.1
• Gene: pitx2 / 30164
• ZFINID: ZDB-GENE-990714-27
• Length: 314
• Species: Danio rerio
• Alignment Length: 450
• Identity: 116/450 - (25%)
• Similarity: 165/450 - (36%)
• Gaps: 177/450 - (39%)

  Fly   452 PRSMEEVHHQQQSHHH--QQQQQQQQQQQQLQQQQGFQHDFRNSGNGNPNGNSNSGDHGERLNAD 514
            |.|::..||    :||  ..:.........||..|                  .|.|...||:..
Zfish     7 PLSLDHHHH----NHHVTGSKHAPLSMASSLQPLQ------------------RSVDSKHRLDVH 49

  Fly   515 SDSLVNGSCASSEDLNQTNSSEQGEKITSGS-DDEGQDDNCAKKKHRRNRTTFTTYQLHELERAF 578
            :             ::.|:|.|..||....| :::..||...||:.||.||.||:.||.|||..|
Zfish    50 T-------------VSDTSSPESVEKEKGQSKNEDSNDDPSKKKRQRRQRTHFTSQQLQELEATF 101

  Fly   579 EKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASG 643
            :::.|||:.:|||:|:..||.|.||:|||:|||||||::|:::...|....|       |...:|
Zfish   102 QRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGF-------GPQFNG 159

  Fly   644 LPVDPWLSPPLLSALPGFLSHPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGH 708
            | :.|:                ..:||||            |.::.||.|
Zfish   160 L-MQPY----------------DDMYPSY------------TYNNWAAKG--------------- 180

  Fly   709 GGHGQPQPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMS-PHATSLGSPHHGVTPLGTPLHSSL 772
                                          ..|..||..| |...|:     .|.||.:....|
Zfish   181 ------------------------------LTSASLSTKSFPFFNSM-----NVNPLSSQTMFS- 209

  Fly   773 PPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSSNPG 837
            ||:|.       ||.|.|||           |.|                       .:.:..||
Zfish   210 PPNSI-------SSMSMSSS-----------MVP-----------------------SAVTGVPG 233

  Fly   838 SSLDKCAASANIE--LLDVGRDSPPPPPTPTGKGSSTPP---TDMRSNSIATLRIKAKEH 892
            |||:......|:.  .|:.|..:|..|..|     .|||   .|..::|:|:||:|||:|
Zfish   234 SSLNSLNNLNNLSNPSLNSGVPTPACPYAP-----PTPPYVYRDTCNSSLASLRLKAKQH 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeodomain	560..616	CDD:459649	33/55 (60%)
		OAR	876..892	CDD:461067	8/15 (53%)
pitx2	NP_571050.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93		29/120 (24%)
		Homeodomain	83..139	CDD:459649	33/55 (60%)
		OAR	272..289	CDD:461067	8/16 (50%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	276..289		7/12 (58%)
		Nuclear localization signal. /evidence=ECO:0000255	282..286		2/3 (67%)