DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rx and ALX3

DIOPT Version :9

Sequence 1:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_006483.2	Gene:	ALX3 / 257	HGNCID:	449	Length:	343	Species:	Homo sapiens

Alignment Length:	417	Identity:	111/417 - (26%)
Similarity:	159/417 - (38%)	Gaps:	112/417 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 SPTGAGPPPPPGAYFMESQTAPVAPSQINYDERSMSSASDLEEDDDDAAKLQLDVTSPPTPSPRG 418
            :|...||.|.|   ::.|...|..|      :.:.::|..|.                |.| |||
Human     7 APFRVGPAPGP---YVASGDEPPGP------QGTPAAAPHLH----------------PAP-PRG 45

  Fly   419 QLAAKRKSAGVFCDDNEPKLANGQLPGGNY----GIRPRSMEEVHHQQQSHHHQQQQQQQQQQQQ 479
                .|.:....|...||.|.....|...|    |..| ::...|..:.....:::..:.....|
Human    46 ----PRLTRFPACGPLEPYLPEPAKPPAKYLQDLGPGP-ALNGGHFYEGPAEAEEKTSKAASFPQ 105

  Fly   480 LQQQ-QGFQHDFRNSGNGNPNGNSNSGDHGERLNADSDSLVNGSCASSEDLNQTNSSEQGEKITS 543
            |... :|...|..::..|:|                      |.|.:|..|..:.......::..
Human   106 LPLDCRGGPRDGPSNLQGSP----------------------GPCLASLHLPLSPGLPDSMELAK 148

  Fly   544 GSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQ 608
            .           |.|.|||||||:|:||.|||:.|:|:||||||:||:||::.:|.|.|||||||
Human   149 N-----------KSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQ 202

  Fly   609 NRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGFLSHPQTVYPSYL 673
            |||||||::|:...::.|...||....                   :|.||...||||.....:.
Human   203 NRRAKWRKRERYGKIQEGRNPFTAAYD-------------------ISVLPRTDSHPQLQNSLWA 248

  Fly   674 TP-------PLSLAPGNLTMSSLAAMGHHH----AHNGPPPPHVGHGGHGQPQPPPPPPPHGVPH 727
            :|       |..::|..:....::...|.|    ...|.|.|...|        |.....||.|.
Human   249 SPGSGSPGGPCLVSPEGIPSPCMSPYSHPHGSVAGFMGVPAPSAAH--------PGIYSIHGFPP 305

  Fly   728 PHGSHHVVPLS---HLSPHL--SRMSP 749
            ..|.|...|.|   :.||.|  .|:.|
Human   306 TLGGHSFEPSSDGDYKSPSLVSLRVKP 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	36/51 (71%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
ALX3	NP_006483.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		25/127 (20%)
		PRK12323	<13..131	CDD:237057	31/170 (18%)
		Homeobox	157..210	CDD:365835	37/52 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920