DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rx and phx1

DIOPT Version :9

Sequence 1:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_593776.1	Gene:	phx1 / 2542405	PomBaseID:	SPAC32A11.03c	Length:	942	Species:	Schizosaccharomyces pombe

Alignment Length:	507	Identity:	115/507 - (22%)
Similarity:	169/507 - (33%)	Gaps:	169/507 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 GQLPGGNYGIRPRSMEEVHHQQQSHHHQQQQQQQQQQQQLQQQQGFQHDFRNS----GNGNPNGN 501
            ||.|..|             ..|..|...:|..|.:||.......|..:|..:    ....|..:
pombe    43 GQFPSDN-------------NMQLPHSTYEQHLQGEQQNPTNPNYFPPEFDENKVDWKQEKPKPD 94

  Fly   502 SNS-GDHGERLNADSDSLVNGS-----CASSEDLNQTNSSEQGEKI--------------TSGSD 546
            :.| .|:....|.:|..|.|.|     ...||  ::..:|:|.|.:              .||:.
pombe    95 APSFADNNSFDNVNSSKLTNPSPVQPNIVKSE--SEPANSKQNEVVEATSVEKAKENVAHESGTP 157

  Fly   547 DEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRR 611
            :.|...:..|.|.:|    .|..||..|.|.|.|...|....||::..::|:||..|.:||||||
pombe   158 ESGGSTSAPKSKKQR----LTADQLAYLLREFSKDTNPPPAIREKIGRELNIPERSVTIWFQNRR 218

  Fly   612 AK----WRRQEKS-----------ESLRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGF 661
            ||    .||||:.           :||...::.  ...|.:   .|..|..|::.        |.
pombe   219 AKSKLISRRQEEERQRILREQRELDSLNQKVSQ--AFAHEV---LSTSPTSPYVG--------GI 270

  Fly   662 LSHPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPHGVP 726
            .::.|  |.:.|.|..:...||..|.|           ||.          |....|......:|
pombe   271 AANRQ--YANTLLPKPTRKTGNFYMKS-----------GPM----------QSSMEPCIAESDIP 312

  Fly   727 HPHGSHHVVPLSHLSPHLSRMSPHATSLGSPH------HGVTPLGTPLHSSL-----PPSSTATT 780
                    :..|..|.:.:.:||:|..:.|..      :...|....:.:..     ||||.||.
pombe   313 --------IRQSLSSTYYNSLSPNAVPVSSQRKYSASSYSAIPNAMSVSNQAFDVESPPSSYATP 369

  Fly   781 VA-----------------VSSSQSS------SSSASLECSGPDVCMSPQNLSIGNADSNGDGRD 822
            :.                 ||.|...      |..:|.:.|||   :.|.|::.|:.
pombe   370 LTGIRMPQPESDLYSYPREVSPSSGGYRMFGHSKPSSYKASGP---VRPPNMATGHM-------- 423

  Fly   823 LSSDLDAGSTSSNPGSSLDKCAASANIELLDVG-----RDSP--------PP 861
                    .|||.| :|.|......:..||.:|     |.||        ||
pombe   424 --------RTSSEP-TSYDSEFYYFSCTLLVIGLWKRLRASPQDLMCFYSPP 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	22/55 (40%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
phx1	NP_593776.1	COG5576	116..272	CDD:227863	45/174 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910