Protein Alignment Rx and Alx1

DIOPT Version :10

• Sequence 1: NP_726006.3
• Gene: Rx / 37367
• FlyBaseID: FBgn0020617
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_001408403.1
• Gene: Alx1 / 216285
• MGIID: 104621
• Length: 377
• Species: Mus musculus
• Alignment Length: 449
• Identity: 109/449 - (24%)
• Similarity: 158/449 - (35%)
• Gaps: 180/449 - (40%)

  Fly   487 QHDFRNSGNGNPNGNSNSG------------DHGERLNADS---DSLVNGSCASSE------DLN 530
            :|......|.:..|.:.:|            :|..||:..|   ||.||......|      :||
Mouse    29 EHVMETLDNESFYGKATAGKCVQAFGPLPRAEHHVRLDRTSPCQDSSVNYGITKVEGQPLHTELN 93

  Fly   531 QT--------NSSEQGEKITSGSDDEGQ--DDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPD 585
            :.        .|..:|....|..|:.|.  |.|.:..|.||:|||||:.||.|||:.|:|:||||
Mouse    94 RAMDNCNNLRMSPVKGMPEKSELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPD 158

  Fly   586 VYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWL 650
            ||.||:||::..|.|.||||||||||||||::|:...::...:||.....
Mouse   159 VYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYD--------------- 208

  Fly   651 SPPLLSALPGFLSHPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQ 715
                :|.||...|:||.        ..:|..||.:..|:..
Mouse   209 ----ISVLPRTDSYPQI--------QNNLWAGNASGGSVVT------------------------ 237

  Fly   716 PPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPH-ATSLGSPHHGVTPLGTPLHSSLPPSSTAT 779
                                         |.|.|. |:|..:|:.         ||   |.:.::
Mouse   238 -----------------------------SCMLPRDASSCMTPYS---------HS---PRTDSS 261

  Fly   780 TVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSSNPGSSLDKCA 844
            ....|:.|:..|...|                        ....:..|..|:|:   |.:.:
Mouse   262 YTGFSNHQNQFSHVPL------------------------NNFFTDSLLTGATN---GHAFE--- 296

  Fly   845 ASANIELLDVGRDSPPPPPTPTGKGSSTPPTDMRSNSIATLRIKAKEHLDNLNKGMVSI 903
                                      :.|..:.||:|||.||:|||||..|::..|..|
Mouse   297 --------------------------TKPEFERRSSSIAVLRMKAKEHTANISWAMFDI 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rx	NP_726006.3	Homeodomain	560..616	CDD:459649	39/55 (71%)
		OAR	876..892	CDD:461067	10/15 (67%)
Alx1	NP_001408403.1	Homeodomain	133..189	CDD:459649	39/55 (71%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		43/281 (15%)
		OAR	302..320	CDD:461067	12/17 (71%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		9/12 (75%)