DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rx and ARX

DIOPT Version :9

Sequence 1:NP_726006.3 Gene:Rx / 37367 FlyBaseID:FBgn0020617 Length:904 Species:Drosophila melanogaster
Sequence 2:NP_620689.1 Gene:ARX / 170302 HGNCID:18060 Length:562 Species:Homo sapiens


Alignment Length:669 Identity:159/669 - (23%)
Similarity:223/669 - (33%) Gaps:259/669 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   318 PAPL-------------PPSSFGSHQQHL--------------------AALAAQAQEQQNQHSK 349
            ||||             |.||....:..|                    ||.||.|.......:.
Human    51 PAPLTSRADPEKAVQGSPKSSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAA 115

  Fly   350 YAKSSPTGAGPPPPP------------GAYFMESQTAPVAPSQINYDERSMSSASDLEEDDDDAA 402
            .|.:.|.|..|||||            ||....:..|..|...:...:....|.|..:...::.|
Human   116 TATAGPRGEAPPPPPPTARPGERPDGAGAAAAAAAAAAAAWDTLKISQAPQVSISRSKSYRENGA 180

  Fly   403 KLQLDVTSPPTPSPRGQLAAKRKSAGVFCDDNEPKLAN--GQLPGGNYGIRPRSMEEVHHQQQSH 465
            ..     .||.|:    |.......||...:....:|.  |..|....|......||...:.:..
Human   181 PF-----VPPPPA----LDELGGPGGVTHPEERLGVAGGPGSAPAAGGGTGTEDDEEELLEDEED 236

  Fly   466 HHQQQQQQQQQQQQLQQQQGFQHDFR------------NSGNGNPNGNSNSGDHGERLNADSDSL 518
            ..::::..:..:::|     .:.|.|            .:|.......:.....|..|:...:.|
Human   237 EDEEEELLEDDEEEL-----LEDDARALLKEPRRCPVAATGAVAAAAAAAVATEGGELSPKEELL 296

  Fly   519 VNGSCASSEDLNQTNSSEQGEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHY 583
            ::...|..:|      .|....:::|||.|   :...|:|.||.|||||:|||.||||||:|:||
Human   297 LHPEDAEGKD------GEDSVCLSAGSDSE---EGLLKRKQRRYRTTFTSYQLEELERAFQKTHY 352

  Fly   584 PDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDP 648
            |||::||||||:::|.|.||||||||||||||::||:.:    .||           ..|||   
Human   353 PDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGA----QTH-----------PPGLP--- 399

  Fly   649 WLSPPLLSALPGFLS--HPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGH 711
                     .||.||  ||       |:|.|..:|         ...||.|.:............
Human   400 ---------FPGPLSATHP-------LSPYLDASP---------FPPHHPALDSAWTAAAAAAAA 439

  Fly   712 GQPQPPPPP-----PPHGVP-------------HPHGSHHVVPLSHLSPHLSRMSPHATSLGSPH 758
            ..|..||||     ||.|.|             ||         :.:||...|            
Human   440 AFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHP---------AFISPAFGR------------ 483

  Fly   759 HGVTPLGTPLHSSLPPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDL 823
                     |.|::.|.::|:|.|....|                                    
Human   484 ---------LFSTMAPLTSASTAAALLRQ------------------------------------ 503

  Fly   824 SSDLDAGSTSSNPGSSLDKCAASANIELLDVGRDSPPPPPTPTGKGS---------STPPTDMRS 879
                                                   |||..:|:         :|...|.|:
Human   504 ---------------------------------------PTPAVEGAVASGALADPATAAADRRA 529

  Fly   880 NSIATLRIKAKEHLDNLNK 898
            :|||.||:|||||...|.:
Human   530 SSIAALRLKAKEHAAQLTQ 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RxNP_726006.3 Homeobox 563..615 CDD:278475 40/51 (78%)
OAR 876..892 CDD:281777 10/15 (67%)
ARXNP_620689.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..81 8/29 (28%)
GCG-encoded polyalanine repeat 102..111 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..255 27/150 (18%)
Homeobox 332..385 CDD:395001 41/52 (79%)
OAR 526..544 CDD:397759 12/17 (71%)
OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138 530..543 9/12 (75%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D454642at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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