DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otp and otpa

DIOPT Version :9

Sequence 1:	NP_001286654.1	Gene:	otp / 37364	FlyBaseID:	FBgn0015524	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001122175.1	Gene:	otpa / 560759	ZFINID:	ZDB-GENE-070216-1	Length:	332	Species:	Danio rerio

Alignment Length:	354	Identity:	144/354 - (40%)
Similarity:	166/354 - (46%)	Gaps:	99/354 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GGGVARLHISGGLCDNSNALNGGN---GSSGNGNGNNNNG---NGNNNNSMQQQDQH------LD 112
            |||...:| .|.|...|:|:.|..   |...|..|:|..|   |..:....|||.|:      ..
Zfish    47 GGGTDPVH-PGDLAPVSDAVEGATLLPGDDINSAGSNPPGVAVNSKDQEKQQQQQQNPTQSSSQQ 110

  Fly   113 KNKQKRHRTRFTPAQLNELERCFSKTHYPDIFMREEIAMRIGLTESRVQVWFQNRRAKWKKRKKT 177
            ..|||||||||||||||||||.|:||||||||||||:|:||||||||||||||||||||||||||
Zfish   111 SQKQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWKKRKKT 175

  Fly   178 TNVFRTPGALLPS-HGLPPF-GANITNIAMGDGLCGTGMFGGD-RWSVGVNPMTAGFGQLNQSSP 239
            |||||.||.|||: ||||.| .|.....||||.||  .....| ||:....|   |..|| |..|
Zfish   176 TNVFRAPGTLLPTHHGLPQFPSAAAAAAAMGDSLC--SFHANDTRWAAAGMP---GVSQL-QLPP 234

  Fly   240 LSSSLNSGLNSGINMGSALGAGSYQHYGLNALGDSMMYQHSVGGVSCGPSGSPSATTPPNMNSCS 304
                                          |||.......|:...|.|      |..|||..|.|
Zfish   235 ------------------------------ALGRQQAMAQSLSQCSLG------AGPPPNSMSLS 263

  Fly   305 SVTPPPLSAQPNSSQNELNGEPMPLHQQQQQQTHQHQQQQTHQHHP----MAPPT---PTQQQQQ 362
            :::.              ||..:                |:|.:.|    |.|.:   ||.....
Zfish   264 NMSS--------------NGSGL----------------QSHLYQPTFPGMVPASLSGPTNVTGS 298

  Fly   363 LPQSMQSP-SDGANDTLHSIAALRRRASE 390
             ||...|| :|....|  |||:|||:|.|
Zfish   299 -PQLCSSPDTDVWRGT--SIASLRRKALE 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otp	NP_001286654.1	Homeobox	119..167	CDD:278475	43/47 (91%)
otpa	NP_001122175.1	Homeobox	117..165	CDD:278475	43/47 (91%)
otpa	NP_001122175.1	OAR	309..326	CDD:281777	9/18 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5919
eggNOG	1	0.900	-	-		E33208_3BA7E
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4009
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1243020at2759
OrthoFinder	1	1.000	-	-		FOG0007109
OrthoInspector	1	1.000	-	-		otm25807
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46770
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4709
SonicParanoid	1	1.000	-	-		X5198
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.960