DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otp and Pitx2

DIOPT Version :9

Sequence 1:	NP_001286654.1	Gene:	otp / 37364	FlyBaseID:	FBgn0015524	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001035970.1	Gene:	Pitx2 / 54284	RGDID:	3331	Length:	324	Species:	Rattus norvegicus

Alignment Length:	331	Identity:	86/331 - (25%)
Similarity:	125/331 - (37%)	Gaps:	117/331 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NNGNGNNNNSMQQQDQHLDKNKQKRHRTRFTPAQLNELERCFSKTHYPDIFMREEIAMRIGLTES 158
            :.|....|..:..:|.. .|.:|:|.||.||..||.|||..|.:..|||:..|||||:...|||:
  Rat    71 DKGQQGKNEDVGAEDPS-KKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEA 134

  Fly   159 RVQVWFQNRRAKWKKRKKTTNVFRTPGALLPSHGLPPFGANITNIAMGDGLCGTGMFGGDRWSVG 223
            ||:|||:||||||:||::....                           .||..|.  |.:::..
  Rat   135 RVRVWFKNRRAKWRKRERNQQA---------------------------ELCKNGF--GPQFNGL 170

  Fly   224 VNP---MTAGFGQLNQSSPLSSSLNSGLNSGINMGSALGAGSYQHYGLNALGDSMMYQHSVGGVS 285
            :.|   |..|:...|.::       .||.|     ::|...|:..:               ..::
  Rat   171 MQPYDDMYPGYSYNNWAA-------KGLTS-----ASLSTKSFPFF---------------NSMN 208

  Fly   286 CGPSGSPSATTPPN----MNSCSSVTPPPLSAQPNSSQNELN------------GEPMPLHQQQQ 334
            ..|..|.|..:|||    |:..||:.|..::..|.||.|.||            ..|.|.
  Rat   209 VNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPA----- 268

  Fly   335 QQTHQHQQQQTHQHHPMAPPTPTQQQQQLPQSMQSPSDGANDTLHSI------------AALRRR 387
                          .|.|||||....:          |..|.:|.|:            |:::..
  Rat   269 --------------CPYAPPTPPYVYR----------DTCNSSLASLRLKAKQHSSFGYASVQNP 309

  Fly   388 ASELNA 393
            ||.|:|
  Rat   310 ASNLSA 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otp	NP_001286654.1	Homeobox	119..167	CDD:278475	26/47 (55%)
Pitx2	NP_001035970.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..111		15/40 (38%)
		Homeobox	96..149	CDD:395001	32/52 (62%)
		OAR	282..299	CDD:397759	4/16 (25%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	286..299		2/12 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	292..296		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I4895
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960