Protein Alignment otp and Pitx1

DIOPT Version :10

• Sequence 1: NP_001286654.1
• Gene: otp / 37364
• FlyBaseID: FBgn0015524
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_446076.1
• Gene: Pitx1 / 113983
• RGDID: 69253
• Length: 315
• Species: Rattus norvegicus
• Alignment Length: 257
• Identity: 84/257 - (32%)
• Similarity: 125/257 - (48%)
• Gaps: 48/257 - (18%)

  Fly    80 NGGNGSSGNGNGNNNNGNGNNNNSMQQQDQHLDKNKQKRHRTRFTPAQLNELERCFSKTHYPDIF 144
            :||.||:|.|:.                :....|.||:|.||.||..||.|||..|.:..|||:.
  Rat    69 DGGAGSAGCGSA----------------EDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMS 117

  Fly   145 MREEIAMRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRTPGALLPSHG--LPPFGANITNIAMGD 207
            ||||||:...|||.||:|||:||||||:||::...:....|..:|...  :.|:          :
  Rat   118 MREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPY----------E 172

  Fly   208 GLCGTGMFGGDRW---SVGVNPM-TAGFGQLNQSSPLSS----SLNSGLNSGINMGSALGAGS-- 262
            .:.....:..:.|   |:...|: |..|...|..|||||    |..|.::| :.|.|::|.||
  Rat   173 DVYAAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISS-MTMPSSMGPGSVP 236

  Fly   263 -YQHYGLNAL----GDSMMYQHSVGGVSCGPSGSPSATTPPNMNSC-SSVTPPPLSAQPNSS 318
             ..:.|||.:    |.|:....|.|  :| |.|:|::......::| ||:....|.::.:||
  Rat   237 GMPNSGLNNINNLTGSSLNSAMSPG--AC-PYGTPASPYSVYRDTCNSSLASLRLKSKQHSS 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
otp	NP_001286654.1	Homeodomain	117..168	CDD:459649	29/50 (58%)
Pitx1	NP_446076.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		16/49 (33%)
		Homeodomain	90..146	CDD:459649	34/55 (62%)
		Interaction with PIT-1. /evidence=ECO:0000250	149..280		33/144 (23%)
		OAR	277..294	CDD:461067	4/16 (25%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	281..294		3/12 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	287..291		1/3 (33%)