DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cib2 and RCVRN

DIOPT Version :9

Sequence 1:	NP_611523.3	Gene:	Cib2 / 37363	FlyBaseID:	FBgn0034558	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_002894.1	Gene:	RCVRN / 5957	HGNCID:	9937	Length:	200	Species:	Homo sapiens

Alignment Length:	184	Identity:	40/184 - (21%)
Similarity:	86/184 - (46%)	Gaps:	25/184 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGN-KVVTFTEQELDDYQDCTFFTRKEILRVHKRFRELRPDLVPRQMTEGQASSVKVPCECIEKM 64
            ||| |....:::.|::.|..|.|:.:|:...::.|.:   |....::|:.|..|:..     :..
Human     1 MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLK---DCPTGRITQQQFQSIYA-----KFF 57

  Fly    65 PELRENPFRRRICEAFSRDGQGNLSFEDFLDALSVFSEQAPRDIKVFYAFKIYDFDQDGFIGHAD 129
            |:.....:.:.:..:|..:..|.|.|::::.||.: :.....:.|:.:||.:||.|.:|.|...:
Human    58 PDTDPKAYAQHVFRSFDSNLDGTLDFKEYVIALHM-TTAGKTNQKLEWAFSLYDVDGNGTISKNE 121

  Fly   130 LMSCLTTMTK------------NELSPEEHQQIADKVIEEADVDGDGKLSILEF 171
            ::..:..:.|            :|.:||:.   |:|:.:....:.|.||:..||
Human   122 VLEIVMAIFKMITPEDVKLLPDDENTPEKR---AEKIWKYFGKNDDDKLTEKEF 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cib2	NP_611523.3	FRQ1	20..180	CDD:227455	34/164 (21%)
RCVRN	NP_002894.1	FRQ1	14..182	CDD:227455	36/171 (21%)
RCVRN	NP_002894.1	Interaction with GRK1. /evidence=ECO:0000250\|UniProtKB:P21457	189..192
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920