DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cib2 and CHP1

DIOPT Version :9

Sequence 1:	NP_611523.3	Gene:	Cib2 / 37363	FlyBaseID:	FBgn0034558	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_009167.1	Gene:	CHP1 / 11261	HGNCID:	17433	Length:	195	Species:	Homo sapiens

Alignment Length:	191	Identity:	56/191 - (29%)
Similarity:	96/191 - (50%)	Gaps:	27/191 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKVVT-FTEQELDDYQDCTFFTRKEILRVHKRFRELRPDLVPRQMTEGQASSVKVPCECIEKM 64
            ||::..| ..::||::.:..|.|:..:|.|::.||..|         .:|:..::.  .|..:::
Human     1 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSL---------DKGENGTLS--REDFQRI 54

  Fly    65 PELRENPFRRRICEAFSRDGQGNLSFEDFLDALSVF----SEQAPRDI-----------KVFYAF 114
            |||..||...||..||..:|:..::|..|:..|:.|    ..:..:|:           |:.:||
Human    55 PELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAF 119

  Fly   115 KIYDFDQDGFIGHADLMSCLTTMTKNELSPEEHQQIADKVIEEADVDGDGKLSILEFEHVI 175
            ::||.|:|..|...:|:..|..|....:|.|:...|||:.|:|||.|||..:|..||..|:
Human   120 RLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cib2	NP_611523.3	FRQ1	20..180	CDD:227455	51/171 (30%)
CHP1	NP_009167.1	FRQ1	1..182	CDD:227455	56/191 (29%)
		Necessary for association with microtubule and interaction with GAPDH. /evidence=ECO:0000250	2..6		1/3 (33%)
		Nuclear export signal 1. /evidence=ECO:0000250	138..147		2/8 (25%)
		Necessary for nuclear export signal	143..185		16/38 (42%)
		Nuclear export signal 2. /evidence=ECO:0000250	176..185		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850